6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one CAS 449811-92-1
| CAS No. | 449811-92-1 |
| Molecular Formula | C19H18F2N4O3 |
| Molecular Weight | 388.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one (CAS 449811-92-1), a certified reference material (molecular formula C19H18F2N4O3, MW 388.37 g/mol) for analytical method development and quality control.
6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one (C19H18F2N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H18F2N4O3 |
| Molecular Weight | 388.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Difluorophenoxy Standards
- Ethyl 4-{[2-(3,4-difluorophenoxy)benzyl]amino}benzenecarboxylate (CAS 477887-08-4)
- N1-[2-(2,4-difluorophenoxy)-3-pyridyl]-2,3,3-trichloroacrylamide (CAS 243644-40-8)
- N1-[6-(2,4-difluorophenoxy)-3-pyridyl]-2,3,3-trichloroacrylamide (CAS 243644-42-0)
- 4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline (CAS 672951-71-2)
- 2-(2,4-Difluorophenoxy)-5-(3-(trifluoromethyl)phenyl)nicotinonitrile (CAS 338964-63-9)
- 2-(2,4-Difluorophenoxy)-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 337921-92-3)
- 4-[6-(2,4-Difluorophenoxy)-2-phenylpyrimidin-4-yl]morpholine (CAS 478067-70-8)
- 6-(2,4-Difluorophenoxy)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one (CAS 449808-50-8)
Recommended Standards
- 5-Hydroxy-3',3,4',5',7-pentamethoxyflavone (CAS 5084-19-5)
- 6-Amino-1-phenyl-4-(thiophen-2-yl)-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (CAS 327169-68-6)
- 4-(3-Nitrophenyl)-2-formyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 5-Isopropyl Ester 3-Methyl Ester (CAS 75530-60-8)
- Artemetin (CAS 479-90-3)
- (1S,2R,4R)-7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid (CAS 1048963-21-8)
- 8-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one (CAS 110766-86-4)
- 3-(3-Methylphenoxy)-1-propanol (CAS 13030-21-2)
- 2-(1-Ethyl-1H-pyrrol-2-yl)ethene-1,1,2-tricarbonitrile (CAS 138596-89-1)
- 3-bromo-1-methyl-1,2-dihydropyridin-2-one (CAS 81971-38-2)
- 3-Ethoxypyrazine-2-carbaldehyde (CAS 910824-50-9)
- Bis-PEG3-sulfonic acid (CAS 255831-16-4)
- (4-Chloro-3-(ethylcarbamoyl)phenyl)boronic acid (CAS 871332-69-3)
- Mirogabalin Impurity 10 (CAS CATO-C4X-292410)
- [14-31]-Semaglutide (CAS CATO-C4X-2226262)
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