4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline CAS 672951-71-2

Purity 97%+In StockPharmaceutical Standards
CAS No.672951-71-2
Molecular FormulaC22H20F2N2OS
Molecular Weight398.47 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline CAS 672951-71-2 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline.

4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline (CAS 672951-71-2), molecular formula C22H20F2N2OS and molecular weight 398.47 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution, 4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 398.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC22H20F2N2OS
Molecular Weight398.47 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)13.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1985
Halogen ContentF-containing
Nitrogen Atoms2
Sulfur Atoms1

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