1-Fluoro-2-iodo-4-methylbenzene CAS 452-82-4
| CAS No. | 452-82-4 |
| Molecular Formula | C7H6FI |
| Molecular Weight | 236.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 1-Fluoro-2-iodo-4-methylbenzene (CAS 452-82-4), a certified reference material (molecular formula C7H6FI, MW 236.03 g/mol) for analytical method development and quality control.
The molecular framework of 1-Fluoro-2-iodo-4-methylbenzene (C7H6FI) is characterized by fluorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6FI |
| Molecular Weight | 236.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/I-containing |
Related Fluoro Standards
- 4-Fluoro-2-iodo-1-methylbenzene (CAS 13194-67-7)
- 1-Fluoro-2-(iodomethyl)benzene (CAS 446-50-4)
- 1-Fluoro-3-(iodomethyl)benzene (CAS 28490-56-4)
- 1-Fluoro-4-(iodomethyl)benzene (CAS 3831-29-6)
- 2-Fluoro-1-iodo-3-methylbenzene (CAS 916420-21-8)
- 2-Fluoro-4-iodotoluene (CAS 39998-81-7)
- 2-Fluoro-5-iodotoluene (CAS 452-68-6)
- 2-Fluoro-6-iodotoluene (CAS 443-85-6)
Recommended Standards
- 1-(fluoromethyl)-3-iodobenzene (CAS 456-45-1)
- 5-Iodothiazole-2-carbonitrile (CAS 1807233-64-2)
- 2-(3-Nitrophenyl)-1,3,6,2-dioxazaborocane (CAS 22237-20-3)
- 5-Iodothiazole-4-carbonitrile (CAS 1804404-88-3)
- 2,6-Bis[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-4-pyridinamine (CAS 860151-85-5)
- Zanubrutinib Related Compound 5 (CAS 960201-86-9)
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- N-Benzyl-1-(2-methyl-1,3-dioxolan-2-yl)cyclopropane-1-carboxamide (CAS 147011-40-3)
- 4,4'-Dimethyl-[2,2'-bithiophene]-5,5'-dicarbaldehyde (CAS 91544-06-8)
- (Z)-4-(5-(4-chlorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid (CAS 17385-93-2)
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- Tau Peptide (337-368) (Repeat 4 Domain) trifluoroacetate salt (CAS 330456-27-4)
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