2-Methyl-5-nitrobenzene-1-sulfonyl fluoride CAS 453-53-2
| CAS No. | 453-53-2 |
| Molecular Formula | C7H6FNO4S |
| Molecular Weight | 219.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Methyl-5-nitrobenzene-1-sulfonyl fluoride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-Methyl-5-nitrobenzene-1-sulfonyl fluoride (CAS 453-53-2) is a high-purity analytical reference standard with the molecular formula C7H6FNO4S and a molecular weight of 219.19 g/mol.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2-Methyl-5-nitrobenzene-1-sulfonyl fluoride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 219.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H6FNO4S |
| Molecular Weight | 219.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 3-Nitrobenzene-1-sulfonohydrazide (CAS 6655-77-2)
- 3-Methyl-4-nitrobenzene-1-sulfonamide (CAS 1250435-32-5)
- 2-methyl-4-nitrobenzene-1-sulfonamide (CAS 22952-19-8)
- 1-Butyl-3-nitrobenzene (CAS 20651-76-7)
- 2-Nitrobenzene-1-sulfonyl Azide (CAS 6655-31-8)
- 2-[(4-nitrobenzene)sulfinyl]acetic acid (CAS 3406-71-1)
- 5-Methyl-2-nitrobenzene-1-sulfonyl chloride (CAS 173908-60-6)
- 4-methyl-3-nitrobenzene-1-sulfonyl chloride (CAS 616-83-1)
Recommended Standards
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- 3-(2,5-Dioxopyrrolidin-1-yl)benzoic acid (CAS 60693-31-4)
- 4-(3-Chlorophenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide (CAS 1707587-09-4)
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- 6-Bromophenanthrene-9-carboxylic acid (CAS 53581-38-7)
- 4-Cyclopropoxy-N-methyl-2-sulfamoylnicotinamide (CAS 1243317-53-4)
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