Tapentadol EP Impurity A CAS 454221-04-6
| CAS No. | 454221-04-6 |
| Molecular Formula | C14H23NO |
| Molecular Weight | 221.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tapentadol EP Impurity A (C14H23NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Tapentadol EP Impurity A (CAS 454221-04-6), a pharmacopoeial impurity reference standard (molecular formula C14H23NO, MW 221.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tapentadol EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H23NO |
| Molecular Weight | 221.34 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Tapentadol Standards
- Tapentadol EP Impurity C (CAS 731764-76-4)
- Tapentadol EP Impurity D (CAS CATO-C4X-209920)
- Tapentadol impurity 7 (CAS 387356-03-8)
- Tapentadol Impurity 10 (CAS 809282-30-2)
- Tapentadol Impurity 14 (CAS CATO-C4X-209914)
- Tapentadol EP Impurity E (CAS 175591-22-7)
- Tapentadol Impurity 16 (CAS CATO-C4X-209916)
- Tapentadol Impurity 18 (CAS CATO-C4X-209918)
Recommended Standards
- Memantine Impurity 67 (CAS CATO-C4X-105867)
- Ivacaftor Impurity 10 (CAS 873055-58-4)
- Memantine Impurity 5 (CAS 19982-07-1)
- Phenylvinyldiethoxysilane (CAS 4652-09-9)
- Montelukast Impurity 26 (CAS 120578-03-2)
- Ciprofloxacin Impurity 28 (CAS CATO-C4X-136228)
- Avatrombopag Impurity 40 (CAS 54127-63-8)
- 5',5''''-(Propane-2,2-diyl)bis(2'-methoxy-[1,1':3',1''-terphenyl]-4,4''-dicarboxylicacid) (CAS 1473420-10-8)
- 5,15-Bis[4-(1,3,2-dioxaborinan-2-yl)phenyl]-21H,23H-porphine (CAS 380449-08-1)
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- 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)cyclopentane-1-carboxylic acid (CAS 512822-51-4)
- Tetrazolo[1,5-a]quinoxalin-4(5H)-one (CAS 29067-85-4)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com