Tadalafil Impurity 29 CAS 474668-76-3
| CAS No. | 474668-76-3 |
| Molecular Formula | C19H16N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tadalafil Impurity 29 (C19H16N2O4HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Tadalafil Impurity 29 (CAS 474668-76-3), a pharmacopoeial impurity reference standard (molecular formula C19H16N2O4HCl, MW 372.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H16N2O4 HCl |
| Molecular Weight | 372.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 10 (CAS 100077-49-4)
- Tadalafil Impurity 75 (CAS 1093940-68-1)
- Tadalafil Impurity 76 (CAS 1093940-70-5)
- Tadalafil Impurity 99 (CAS 114152-23-7)
- Tadalafil Impurity 11 HCl (CAS 1190238-20-0)
- 【禁售不询】Tadalafil Impurity 43 (CAS 120-57-0)
- Tadalafil Impurity N1 (CAS 1220393-12-3)
- Tadalafil Impurity 119 (CAS 130812-44-1)
Recommended Standards
- Naproxen EP Impurity B (CAS 89617-86-7)
- Pelubiprofen Impurity N1 (CAS 63476-54-0)
- Itraconazole Impurity 94 (CAS CATO-C4X-149794)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
- 2-(4-Methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)acetic acid (CAS 726-88-5)
- 1-Benzyl-5-hydroxy-5-methyl-2-phenylpiperidin-4-one (CAS 339261-17-5)
- Dimethyl 4,4'-((2,4-dioxopyrimidine-1,3(2H,4H)-diyl)bis(methylene))dibenzoate (CAS 4113-94-4)
- 2-(Difluoromethyl)-4-hydroxy-3-methoxypyridine-5-sulfonamide (CAS 1805533-12-3)
- 4-Bromo-1-cyclopropyl-1H-benzo[d]imidazol-2-ol (CAS 1416714-00-5)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com