Naproxen EP Impurity B CAS 89617-86-7
| CAS No. | 89617-86-7 |
| Molecular Formula | C14H13ClO3 |
| Molecular Weight | 264.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Naproxen EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Naproxen EP Impurity B (CAS 89617-86-7, C14H13ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Naproxen EP Impurity B (C14H13ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 264.70 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H13ClO3 |
| Molecular Weight | 264.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
Related Naproxen Standards
- Naproxen EP Impurity B (CAS 60424-17-1)
- 51091-84-0 Naproxen acid chloride d-2-(6-Methoxy-2-naphthyl)propionyl chloride Naproxen chloride (CAS 51091-84-0)
- Naproxen Impurity 5 (CAS 37961-57-2)
- Naproxen EP Impurity F (CAS 31220-35-6)
- Naproxen Sodium Impurity O (CAS 156967-24-7)
- rac-Naproxen 2-Propyl Ester (CAS 68641-85-0)
- Naproxen Impurity 45 (CAS CATO-C4X-170845)
- Naproxen Impurity 50 (CAS CATO-C4X-170850)
Recommended Standards
- 2-[2-(3-chlorophenyl)-2-oxoethyl]-1,3-cyclohexanedione 251310-31-3 KS-00002XEH (CAS 251310-31-3)
- 1-(2-Chlorophenyl)-5-(propan-2-yl)-1h-pyrazole-4-carboxylic acid (CAS 1002249-52-6)
- 1-(3-chlorophenyl)-5-isopropyl-1H-pyrazole-4-carboxylic acid (CAS 1004043-11-1)
- 5-(4-Chloro-3,5-dimethylphenoxymethyl)furan-2-carbaldehyde (CAS 438220-14-5)
- Lacosamide EP Impurity J HCl (CAS 3287-99-8)
- Dobutamine Impurity 60 (CAS 63434-00-4)
- Travoprost Impurity 15 (CAS 208111-99-3)
- (R)-2-(4-Chlorophenyl)pyrrolidine (CAS 1217831-54-3)
- 3-Amino-5-propylpyrazole (CAS 126748-58-1)
- Methyl 4-methoxy-3-sulfamoylbenzoate (CAS 38499-95-5)
- 2-Methyl-3-[3-(trifluoromethyl)phenyl]-2-propenal (CAS 1563417-75-3)
- Ethyl 4-(pyridin-3-yl)piperidine-4-carboxylate (CAS 1191123-72-4)
- 2-(Bromomethyl)-6-(difluoromethyl)-3-methylpyridine-5-acetic acid (CAS 1361898-44-3)
- Hippocampal Cholinergic Neurostimulating Peptide (CAS 140158-49-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com