Metoclopramide impurity 69 CAS 476614-92-3
| CAS No. | 476614-92-3 |
| Molecular Formula | C12H14ClNO4 |
| Molecular Weight | 271.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 271.70 g/mol gives Metoclopramide impurity 69 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Metoclopramide impurity 69 (CAS 476614-92-3, C12H14ClNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Metoclopramide impurity 69 (C12H14ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 271.70 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14ClNO4 |
| Molecular Weight | 271.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Metoclopramide Standards
- Metoclopramide Dimethyl Analog (CAS 18094-92-3)
- Metoclopramide N-Desethyl (CAS 27260-19-1)
- Metoclopramide Impurity 130 (CAS CATO-C4X-1415130)
- Metoclopramide Impurity N1 (CAS 3761-48-6)
- Metoclopramide impurity 131 (CAS 40080-43-1)
- Metoclopramide Impurity 118 (CAS CATO-C4X-1415118)
- Metoclopramide Impurity 87 (CAS CATO-C4X-141587)
- Metoclopramide Impurity 107 (CAS CATO-C4X-1415107)
Recommended Standards
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- 1220033-13-5 N-Benzyl-N-ethyl-2-(4-piperidinyl)-1-ethanaminedihydrochloride (CAS 1220033-13-5)
- (3-Bromophenyl)(3,4-dimethoxyphenyl)methanol (CAS 1283139-60-5)
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