2-(3,4-Dichlorophenyl)-6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine CAS 477858-75-6
| CAS No. | 477858-75-6 |
| Molecular Formula | C18H11Cl2FN4 |
| Molecular Weight | 373.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3,4-Dichlorophenyl)-6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-(3,4-Dichlorophenyl)-6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine (CAS 477858-75-6), a certified reference material (molecular formula C18H11Cl2FN4, MW 373.21 g/mol) for analytical method development and quality control.
The molecular framework of 2-(3,4-Dichlorophenyl)-6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine (C18H11Cl2FN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(3,4-Dichlorophenyl)-6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H11Cl2FN4 |
| Molecular Weight | 373.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dichlorophenyl Standards
- 1-[(2,4-Dichlorophenyl)methyl]-6-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 252058-77-8)
- 1-[(2,6-Dichlorophenyl)methyl]-6-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 252058-78-9)
- 1-[(3,4-Dichlorophenyl)methyl]-6-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 252058-80-3)
- 1-(3,5-Dichlorophenyl)-3-(6-methoxynaphthalen-2-yl)propane-1,3-dione (CAS 924887-13-8)
- 1-[(2,4-Dichlorophenyl)methyl]-6-oxo-N-phenyl-1,6-dihydropyridine-3-carboxamide (CAS 242797-37-1)
- 3-(5-(2,3-Dichlorophenyl)furan-2-yl)-1-(4-methoxyphenyl)prop-2-en-1-one (CAS 304896-55-7)
- (3Z)-3-{[(2,4-dichlorophenyl)methoxy]imino}-N-(2,4-difluorophenyl)propanamide (CAS 320417-98-9)
- (3Z)-3-{[(2,6-dichlorophenyl)methoxy]imino}-N-(2,4-difluorophenyl)propanamide (CAS 320418-07-3)
Recommended Standards
- 2-[2,4-Bis(trifluoromethyl)imidazo[1,2-a]1,8-naphthyridin-8-yl]-1,3,4-oxadiazole (CAS 691868-88-9)
- 1-[(2-Chloro-6-fluorophenyl)methyl]-6-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 400089-27-2)
- n-(3-Iodophenyl)-3-methylbenzenesulfonamide (CAS 560996-47-6)
- 1-[(2-Chloro-6-fluorophenyl)methyl]-6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 252059-16-8)
- 3-Ethyl-5-(4-(piperazin-1-yl)pyrimidin-5-yl)-1,2,4-oxadiazole (CAS 1707394-69-1)
- N1-((3,5-dimethyl-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine trihydrochloride (CAS 1337879-50-1)
- Boc-His(Trt)-Aib-Glu(OtBu)-OH (CAS CATO-C4X-2226230)
- (5-(2,5-Difluorophenyl)pyridin-3-yl)methanol (CAS 887974-23-4)
- Dexamethasone Impurity 55 (CAS CATO-C4X-116555)
- 4-[benzyl(methyl)amino]-3-hydroxybutanoic acid (CAS 1548471-02-8)
- 4-chloropyrimidine-2-carbonitrile (CAS 898044-48-9)
- 3-Amino-2-bromo-5-fluoronaphthalene-1,4-dione (CAS 192718-93-7)
- N-(4-Chloro-3-cyclopropoxyphenyl)methanesulfonamide (CAS 1243381-24-9)
- A-18-F-NH2; Morphine Modulating Neuropeptide (CAS 99588-52-0)
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