Flurbiprofen Impurity 9 CAS 477860-13-2
| CAS No. | 477860-13-2 |
| Molecular Formula | C12H9FO |
| Molecular Weight | 188.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Flurbiprofen Impurity 9 (CAS 477860-13-2) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9FO and a molecular weight of 188.20 g/mol.
Flurbiprofen Impurity 9 (C12H9FO) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H9FO |
| Molecular Weight | 188.20 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 82 (CAS 37847-52-2)
- Flurbiprofen Impurity N1 (CAS 81937-33-9)
- Flurbiprofen Impurity 41 (CAS 535-11-5)
- Flurbiprofen Impurity 74 (CAS CATO-C4X-144474)
- Flurbiprofen Impurity 163 (CAS 374936-00-2)
- Flurbiprofen Impurity 12 (CAS 55258-76-9)
- Flurbiprofen Impurity 42 (CAS CATO-C4X-144442)
- Flurbiprofen Impurity 87 (CAS 65487-32-3)
Recommended Standards
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- Phenylephrine Impurity 36 (CAS CATO-C4X-146736)
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- Methyl (S)-3-methoxypyrrolidine-3-carboxylate (CAS 942190-58-1)
- 2-(3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)acetic Acid (CAS 106660-11-1)
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- Empagliflozin Impurity 98 (CAS CATO-C4X-106598)
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