Flurbiprofen Impurity N1 CAS 81937-33-9
| CAS No. | 81937-33-9 |
| Molecular Formula | C9H10FNO2 |
| Molecular Weight | 183.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Flurbiprofen Impurity N1 (CAS 81937-33-9) is a certified pharmaceutical impurity reference standard with the molecular formula C9H10FNO2 and a molecular weight of 183.18 g/mol.
Structurally, Flurbiprofen Impurity N1 (C9H10FNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 183.18 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Flurbiprofen Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10FNO2 |
| Molecular Weight | 183.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 41 (CAS 535-11-5)
- Flurbiprofen Impurity 9 (CAS 477860-13-2)
- Flurbiprofen Impurity 82 (CAS 37847-52-2)
- Flurbiprofen Impurity 42 (CAS CATO-C4X-144442)
- Flurbiprofen Impurity 74 (CAS CATO-C4X-144474)
- Flurbiprofen Impurity 87 (CAS 65487-32-3)
- Flurbiprofen Impurity 89 (CAS 75908-73-5)
- Flurbiprofen Impurity 163 (CAS 374936-00-2)
Recommended Standards
- Saccharin (CAS 81-07-2)
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- Esomeprazole Impurity 92 (CAS 3718-65-8)
- Acemetacin EP Impurity D (CAS 76812-64-1)
- Alendronic Acid Impurity 5 (CAS CATO-C4X-22425)
- But-2-ene-1,4-diamine (CAS 18231-61-3)
- N1,N1-Bis(1-amino-2-methylpropan-2-yl)oxalamide (CAS 189684-25-1)
- 2-Formyl-4-methylpentanenitrile (CAS 63726-64-7)
- 1-((5-Bromofuran-2-yl)methyl)azetidine-3-carboxylic acid (CAS 1339366-50-5)
- N-((1-(2-Aminoacetyl)pyrrolidin-3-yl)methyl)-N-cyclopropylacetamide (CAS 1353966-20-7)
- tert-Butyl 4-[(2z)-2-(hydroxyimino)-2-(4-methoxyphenyl)ethyl]piperazine-1-carboxylate (CAS 904815-72-1)
- Tetrapeptide-3 (CAS 827306-97-8)
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