2-{4-[(4-methylphenyl)methoxy]phenyl}-4-(thiophen-2-yl)pyrimidine CAS 477862-32-1
| CAS No. | 477862-32-1 |
| Molecular Formula | C22H18N2OS |
| Molecular Weight | 358.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-{4-[(4-methylphenyl)methoxy]phenyl}-4-(thiophen-2-yl)pyrimidine is closely related to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-{4-[(4-methylphenyl)methoxy]phenyl}-4-(thiophen-2-yl)pyrimidine (CAS 477862-32-1) is a high-purity analytical reference standard with the molecular formula C22H18N2OS and a molecular weight of 358.46 g/mol.
The molecular framework of 2-{4-[(4-methylphenyl)methoxy]phenyl}-4-(thiophen-2-yl)pyrimidine (C22H18N2OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18N2OS |
| Molecular Weight | 358.46 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 2,3-Difluoro-4-[4-(trans-4-pentylcyclohexyl)phenyl]phenol (CAS 437625-60-0)
- 4-([1,1'-biphenyl]-4-yl)-N-(2-methoxyphenyl)thiazol-2-amine (CAS 339204-45-4)
- 4-(5-(Benzylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)aniline (CAS 835618-62-7)
- 2-(2-(3-Cyclohexylureido)thiazol-4-yl)-N-phenylacetamide (CAS 921487-92-5)
- 2-(3-Chloro-5-fluoropyridin-2-yl)acetonitrile (CAS 1227591-40-3)
- 1-((2-Phenoxyethyl)sulfonyl)-4-(thiophen-2-yl)piperidine (CAS 1428380-78-2)
- 2-Bromo-4-methyl-6-(trifluoromethyl)pyridine (CAS 615580-44-4)
- 1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethan-1-one (CAS 1125828-30-9)
- 6-Amino-4-methoxypyrimidin-2(1H)-one (CAS 29626-48-0)
- N-methyl-3-(tetrahydrofuran-2-yl)propan-1-amine (CAS 7179-89-7)
- 3-Amino-4-oxohexahydro-2H-pyrrolo[2,1-b][1,3]oxazine-6-carboxylic acid (CAS 349101-93-5)
- 2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)thiazole-5-carboxylic acid (CAS 2137636-91-8)
- 2-Bromopiperidine (CAS 59192-02-8)
- D-[Ser]8-Liraglutide (CAS CATO-C4X-199238)
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