N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-3,4,5-trimethoxybenzohydrazide CAS 477886-80-9
| CAS No. | 477886-80-9 |
| Molecular Formula | C23H21ClN2O5 |
| Molecular Weight | 440.88 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-3,4,5-trimethoxybenzohydrazide is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-3,4,5-trimethoxybenzohydrazide (CAS 477886-80-9), molecular formula C23H21ClN2O5 and molecular weight 440.88 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-3,4,5-trimethoxybenzohydrazide (C23H21ClN2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-3,4,5-trimethoxybenzohydrazide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H21ClN2O5 |
| Molecular Weight | 440.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 2-([1,1'-Biphenyl]-4-yloxy)-1,4-diamino-7-chloroanthracene-9,10-dione (CAS 88605-36-1)
- Tadalafil Impurity 158 (CAS 1863191-32-5)
- 2-([1,1'-Biphenyl]-4-yloxy)-1,4-diamino-6-chloroanthracene-9,10-dione (CAS 88605-25-8)
- Tadalafil Impurity 48 (CAS CATO-C4X-108748)
- 3-Hydroxy-5-iodobenzenesulfonamide (CAS 1243365-19-6)
- 2-Chloro-2-[2-(3,4-dichlorophenyl)hydrazono]-N,N-dimethylacetamide (CAS 1000575-76-7)
- (2-((Dibutylamino)methyl)phenyl)boronic acid (CAS 1312921-42-8)
- (S)-2,2,2-trifluoro-1-(pyridin-4-yl)ethan-1-amine hydrochloride (CAS 2007920-35-4)
- (4r)-2-(3-Hydroxy-4-methoxyphenyl)thiazolidine-4-carboxylic acid (CAS 1212456-87-5)
- 2-(Butylthio)naphthalene-1,4-dione (CAS 59094-49-4)
- 6-(chloromethyl)-5-ethoxy-2-methyl-2,3-dihydro-1-benzofuran (CAS 877977-41-8)
- 2-Oxazoleacetonitrile (CAS 809533-78-6)
- 3-[(2-methyl-1,3-thiazol-5-yl)methyl]benzoic acid hydrochloride (CAS 1354951-94-2)
- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
Why CATO?
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