Tadalafil Impurity 48 CAS CATO-C4X-108748
| CAS No. | CATO-C4X-108748 |
| Molecular Formula | C23H21ClN2O5 |
| Molecular Weight | 440.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Tadalafil Impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Tadalafil Impurity 48 (CAS CATO-C4X-108748), a pharmacopoeial impurity reference standard (molecular formula C23H21ClN2O5, MW 440.88 g/mol) used for the identification and quantification of trace impurities in APIs.
Tadalafil Impurity 48 (C23H21ClN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H21ClN2O5 |
| Molecular Weight | 440.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 158 (CAS 1863191-32-5)
- Tadalafil Impurity 183 (CAS CATO-C4X-1087183)
- Tadalafil Impurity 54 (CAS 171596-32-0)
- Tadalafil Impurity 157 (CAS CATO-C4X-1087157)
- Tadalafil Impurity 177 (CAS CATO-C4X-1087177)
- Tadalafil Impurity 35 (CAS 2169996-11-4)
- Tadalafil Impurity 59 (CAS CATO-C4X-108759)
- Tadalafil Impurity 80 (CAS CATO-C4X-108780)
Recommended Standards
- Lenvatinib Impurity 179 (CAS CATO-C4X-1140179)
- N'-[(1E)-[2-(4-Chlorophenoxy)phenyl]methylidene]-3,4,5-trimethoxybenzohydrazide (CAS 477886-80-9)
- Darolutamide Impurity 47 (CAS CATO-C4X-310647)
- 2-([1,1'-Biphenyl]-4-yloxy)-1,4-diamino-7-chloroanthracene-9,10-dione (CAS 88605-36-1)
- Sugammadex Impurity 43 (CAS 1378831-29-8)
- Deoxycholic acid Impurity 45 (CAS CATO-C4X-335945)
- Telmisartan Impurity 11 (CAS 884330-09-0)
- Cefcapene Impurity 41 (CAS 140128-29-6)
- 1-(5-(4-Chlorophenyl)thiophen-2-yl)ethan-1-amine (CAS 1094424-71-1)
- Tirofiban Impurity 109 (CAS CATO-C4X-1254109)
- Ceritinib Impurity 24 (CAS CATO-C4X-104824)
- Ampicillin Impurity 17 (CAS CATO-C4X-144317)
- 10-(2-Ethylhexyl)-10H-phenothiazine (CAS 264264-00-8)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com