(E)-N'-(3-(trifluoromethyl)benzylidene)-4,5-dihydronaphtho[1,2-b]thiophene-2-carbohydrazide CAS 478033-52-2
| CAS No. | 478033-52-2 |
| Molecular Formula | C21H15F3N2OS |
| Molecular Weight | 400.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 400.42 g/mol gives (E)-N'-(3-(trifluoromethyl)benzylidene)-4,5-dihydronaphtho[1,2-b]thiophene-2-carbohydrazide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(E)-N'-(3-(trifluoromethyl)benzylidene)-4,5-dihydronaphtho[1,2-b]thiophene-2-carbohydrazide (CAS 478033-52-2), molecular formula C21H15F3N2OS and molecular weight 400.42 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-N'-(3-(trifluoromethyl)benzylidene)-4,5-dihydronaphtho[1,2-b]thiophene-2-carbohydrazide (C21H15F3N2OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (E)-N'-(3-(trifluoromethyl)benzylidene)-4,5-dihydronaphtho[1,2-b]thiophene-2-carbohydrazide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H15F3N2OS |
| Molecular Weight | 400.42 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Recommended Standards
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