6-(2-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile CAS 478049-44-4
| CAS No. | 478049-44-4 |
| Molecular Formula | C23H12ClF3N2O |
| Molecular Weight | 424.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-(2-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-(2-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 478049-44-4) is a high-purity analytical reference standard with the molecular formula C23H12ClF3N2O and a molecular weight of 424.80 g/mol.
6-(2-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile (C23H12ClF3N2O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(2-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H12ClF3N2O |
| Molecular Weight | 424.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 6-(3-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 338963-36-3)
- 6-(4-Chlorophenyl)-2-(naphthalen-2-yloxy)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 338963-46-5)
- 2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-3-phenyl-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 692287-35-7)
- Methyl 1-(4-chlorophenyl)-6-oxo-4-[3-(trifluoromethyl)phenoxy]-1,6-dihydropyridazine-3-carboxylate (CAS 338405-39-3)
- 1-[2-(2-chlorophenyl)-2-oxoethyl]-3-[3-(trifluoromethyl)benzyl]-1H-imidazole-2,4,5(3H)-trione 303986-59-6 KS-00002ZQN (CAS 303986-59-6)
- 4-((4-Chlorophenyl)sulfonyl)-2-(2-fluorophenyl)-N-(3-methoxypropyl)oxazol-5-amine (CAS 823829-89-6)
- 1-(4-{4-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]piperidin-1-yl}-3-nitrophenyl)ethan-1-one (CAS 1030856-24-6)
- 2-{[(4-chlorophenyl)carbamoyl]amino}-2-phenylethyl 4-methoxybenzoate (CAS 343373-26-2)
Recommended Standards
- 3-Bromo-2,6-diiodophenol (CAS 28165-58-4)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-N,N-dimethyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide (CAS 339106-91-1)
- 2-(((4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)imino)methyl)-3-hydroxy-5-methylcyclohex-2-en-1-one (CAS 946387-27-5)
- Dimethyl 2,2'-((2-(2-chloro-6-fluorobenzyl)-4-formyl-1,3-phenylene)bis(oxy))diacetate (CAS 303994-40-3)
- 2-Amino-2-ethylbutanenitrile hydrochloride (CAS 859081-90-6)
- 1-Butyl-4-chloro-1h-pyrazole-3-carboxylic acid (CAS 1006451-25-7)
- 6-Phenylimidazo[1,2-a]pyridine-2-carboxylic acid (CAS 1173694-02-4)
- (2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(3-chlorophenyl)prop-2-en-1-one (CAS 1352347-03-5)
- 2-(1H-1,2,3-Triazol-1-yl)benzoic acid (CAS 1085458-53-2)
- (3-Bromophenyl)-pyridin-2-ylmethanol (CAS 856957-26-1)
- N-(3,5-dimethylphenyl)-2-((2,3,4,5,6-pentamethylbenzyl)thio)acetamide (CAS 329079-47-2)
- 5-Amino-1-(2-fluorophenyl)-N-hydroxy-1H-pyrazole-4-carboximidamide (CAS 89433-80-7)
- 3-[(2-fluorobenzoyl)amino]-4-methylbenzoic acid (CAS 926237-97-0)
- Crustacean Cardioactive Peptide (CAS 107090-96-0)
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