2-{[(4-methylphenyl)methyl]sulfanyl}-4-[(4-methylphenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline CAS 478049-64-8
| CAS No. | 478049-64-8 |
| Molecular Formula | C23H24N2S2 |
| Molecular Weight | 392.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-{[(4-methylphenyl)methyl]sulfanyl}-4-[(4-methylphenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline.
2-{[(4-methylphenyl)methyl]sulfanyl}-4-[(4-methylphenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline (CAS 478049-64-8), molecular formula C23H24N2S2 and molecular weight 392.58 g/mol, is a CATO reference standard with documented purity and traceability.
2-{[(4-methylphenyl)methyl]sulfanyl}-4-[(4-methylphenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline (C23H24N2S2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-{[(4-methylphenyl)methyl]sulfanyl}-4-[(4-methylphenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H24N2S2 |
| Molecular Weight | 392.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related methylphenyl Standards
- 2-{[(4-methylphenyl)methyl]sulfanyl}-4-[(3-methylphenyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline (CAS 343374-10-7)
- 4-[(1E)-3-(4-Methylphenyl)-3-oxoprop-1-en-1-yl]phenyl decanoate (CAS 331460-41-4)
- 1-[({5-[(3-methylphenyl)amino]-1,3,4-thiadiazol-2-yl}thio)acetyl]piperidine-4-carboxylic acid (CAS 731801-14-2)
- 2-Methyl-6-(4-methylphenyl)-4-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamide (CAS 866018-29-3)
- 2-(4-Methylphenyl)-4-[(4-methylphenyl)sulfanyl]-5-(morpholin-4-yl)-2,3-dihydropyridazin-3-one (CAS 478067-00-4)
- N-(2-Methylphenyl)-2-[5-(morpholine-4-sulfonyl)-2-oxo-1,2-dihydropyridin-1-yl]acetamide (CAS 1251685-08-1)
- 3-(4-Methylphenyl)-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}prop-2-enamide (CAS 324562-68-7)
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Recommended Standards
- AUDA (CAS 479413-70-2)
- 2-((4-(Tert-butyl)benzyl)thio)-9-methyl-5H-thiochromeno[4,3-d]pyrimidine (CAS 478246-85-4)
- Ethyl 3-{4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}propanoate (CAS 2173991-91-6)
- (5S,6E,8Z,10E,12R,14Z)-N-(3-Aminopropyl)-5,12-dihydroxyicosa-6,8,10,14-tetraenamide (CAS 89596-43-0)
- Icatibant Acetate (CAS 138614-30-9)
- 1-[1-(propan-2-yl)piperidin-4-yl]piperazine (CAS 794494-90-9)
- 3-(3-Bromo-5-methylphenyl)propanoic acid (CAS 1261671-45-7)
- Butylphthalide Impurity 36 (CAS 2245275-82-3)
- N-(4-Fluoroophenylsulfonyl)-DL-alanine (CAS 250714-64-8)
- N-(2-Chlorobenzyl)piperidin-4-amine hydrochloride (CAS 1261230-67-4)
- 6-O-Feruloylsucrose (CAS 137941-45-8)
- 1,1-Dimethylethyl 4-(10-oxo-12-phenyl-3,6,11-trioxa-9-azadodec-1-yl)-1-piperazinecarboxylate (CAS 2382771-34-6)
- 3-(Allylcarbamoyl)benzoic acid (CAS 1154950-54-5)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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