Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-{[(4-methylphenyl)methyl]carbamoyl}acetate CAS 478063-73-9
| CAS No. | 478063-73-9 |
| Molecular Formula | C19H18ClF3N2O3 |
| Molecular Weight | 414.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-{[(4-methylphenyl)methyl]carbamoyl}acetate is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-{[(4-methylphenyl)methyl]carbamoyl}acetate (CAS 478063-73-9), a certified reference material (molecular formula C19H18ClF3N2O3, MW 414.81 g/mol) for analytical method development and quality control.
The molecular framework of Ethyl 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-{[(4-methylphenyl)methyl]carbamoyl}acetate (C19H18ClF3N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H18ClF3N2O3 |
| Molecular Weight | 414.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
- N-[2-chloro-5-(trifluoromethyl)phenyl]-N'-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-Urea (CAS 1211298-93-9)
- N-(3-Chloro-4-methoxyphenyl)-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxamide (CAS 1775546-35-4)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl 4-methoxybenzoate (CAS 306976-41-0)
- 2-(N-((4-Chloro-6-methoxypyrimidin-2-yl)carbamoyl)sulfamoyl)ethyl benzoate (CAS 94365-91-0)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-9-hydroxy-3,5-dioxo-4-azatricyclo[5.2.1.0^{2,6}]decane-8-carbonitrile (CAS 1005068-81-4)
- 1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-6-[(2E)-2-(methoxyimino)ethyl]-4-oxo-1,4-dihydropyrimidine-5-carbonitrile (CAS 303148-49-4)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-(2,4-dimethoxyphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 861206-40-8)
- 2-Chloro-N-(2-((2-cyano-4-nitrophenyl)diazenyl)-5-(diethylamino)phenyl)acetamide (CAS 64294-88-8)
Recommended Standards
- Methyl 4-{[2-(4-chlorobenzamido)-4-(trifluoromethyl)phenyl]amino}butanoate (CAS 339101-69-8)
- (3E)-1-[(2-Chlorophenyl)methyl]-3-{[3-(trifluoromethyl)phenyl]imino}-2,3-dihydro-1H-indol-2-one (CAS 478031-73-1)
- Phenylmercury salicylate(Technical) (CAS 28086-13-7)
- Chlorimuron-Ethyl (CAS 90982-32-4)
- 2-(1H-Indol-3-yl)-2-oxo-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]acetamide (CAS 1024338-95-1)
- 3-[2-(Dimethylamino)ethoxy]aniline HydrochlorideDISCONTINUED PLEASE SEE D400830 (CAS 1089278-93-2)
- (3-Isopropoxyphenyl)(pyridin-2-yl)methanone (CAS 1443306-18-0)
- (S)-N-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)morpholine-4-carboxamide (CAS 69630-22-4)
- Tert-butyl 2-(1-hydroxycyclopropyl)piperazine-1-carboxylate (CAS 1589565-24-1)
- 3-Fluoro-6-methylpyridin-2-amine (CAS 1211520-83-0)
- Hydroxyacetic Acid Hydrazide (CAS 3530-14-1)
- 7-Nitro-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (CAS 93587-26-9)
- (2-Hydroxypropyl)propyl S-Ethyl Ester Carbamothioic Acid (CAS 65109-69-5)
- (Ser(PO3H2)202,Thr(PO3H2)205)-Tau Peptide (194-213) trifluoroacetate salt (CAS 2022956-55-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com