2-[4-(4-Chloro-3-fluorophenoxy)phenyl]-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile CAS 478248-04-3
| CAS No. | 478248-04-3 |
| Molecular Formula | C25H13ClF4N2O |
| Molecular Weight | 468.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-[4-(4-Chloro-3-fluorophenoxy)phenyl]-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 478248-04-3), a certified reference material (molecular formula C25H13ClF4N2O, MW 468.83 g/mol) for analytical method development and quality control.
The molecular framework of 2-[4-(4-Chloro-3-fluorophenoxy)phenyl]-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile (C25H13ClF4N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2-[4-(4-Chloro-3-fluorophenoxy)phenyl]-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H13ClF4N2O |
| Molecular Weight | 468.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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Recommended Standards
- Delafloxacin impurity 33 (CAS 1620905-72-7)
- 4-(4-Chlorophenyl)-2-(4-fluorophenoxy)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 303984-59-0)
- BMS-794833 (CAS 1174046-72-0)
- 2-((4-Bromophenyl)thio)-3-((4-chlorophenyl)sulfonyl)-4,6-dimethylpyridine (CAS 478262-70-3)
- tert-butyl allyl(2,6-dichloropyrimidin-4-yl)carbamate (CAS 1242674-90-3)
- {4-[4-(Piperidinocarbonyl)phenyl]phenyl}acetic acid (CAS 1375069-29-6)
- Methyl (r)-3-(1-amino-2-hydroxyethyl)benzoate (CAS 1213570-07-0)
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- 1-Methanesulfonyl-4-pyridin-3-ylmethyl-[1,4]diazepane-6-carboxylic acid (CAS 1316221-28-9)
- Methyl 6,8-dichloro-2-oxo-2H-chromene-3-carboxylate (CAS 947264-93-9)
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