2-(2,4-Difluorophenoxy)-1-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)propan-1-one CAS 478248-75-8
| CAS No. | 478248-75-8 |
| Molecular Formula | C18H12F5N3O3 |
| Molecular Weight | 413.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-(2,4-Difluorophenoxy)-1-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)propan-1-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 413.30 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-(2,4-Difluorophenoxy)-1-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)propan-1-one (CAS 478248-75-8), a certified reference material (molecular formula C18H12F5N3O3, MW 413.30 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(2,4-Difluorophenoxy)-1-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)propan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H12F5N3O3 |
| Molecular Weight | 413.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluorophenoxy Standards
- 2-(4-(2,4-Difluorophenoxy)-2-oxopyridin-1(2H)-yl)-4-methyl-N-(1-methyl-1H-pyrazol-3-yl)pentanamide (CAS 1262239-23-5)
- [4-(2,4-Difluorophenoxy)-3-nitrophenyl]methyl 3-chlorobenzoate (CAS 338960-94-4)
- 3-(2-(2,4-Difluorophenoxy)-6-oxo-6H-pyrido[1,2-b]pyridazin-5-yl)-4-methoxybenzoic acid (CAS 940891-82-7)
- 2-(2,4-Difluorophenoxy)-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 337921-92-3)
- 4-(2,4-Difluorophenoxy)-2-((4-methylbenzyl)thio)-5,6,7,8-tetrahydroquinazoline (CAS 672951-71-2)
- 2-({4-[(2,4-difluorophenoxy)methyl]-2-nitrophenyl}sulfanyl)-1,3-benzothiazole (CAS 477869-54-8)
- [4-(2,4-Difluorophenoxy)-3-nitrophenyl]methyl N-(4-chlorophenyl)carbamate (CAS 338960-96-6)
- (1E)-1-[2-(3,4-Difluorophenoxy)phenyl]-N-(4-iodophenyl)methanimine (CAS 477886-91-2)
Recommended Standards
- 1-(2-(1H-indol-3-yl)ethyl)-3-(2,4-dichlorobenzyl)-4-hydroxypyridin-2(1H)-one (CAS 478045-90-8)
- N'-[(1E)-{4-[(2,4-dichlorophenyl)methoxy]phenyl}methylidene]-2-phenylacetohydrazide (CAS 329777-94-8)
- N3-PEG3-C2-PFP ester (CAS 1807530-07-9)
- Terbutaline Impurity 49 (CAS CATO-C4X-118349)
- Ethyl 8'-apo-β-caroten-8'-oate (CAS 1109-11-1)
- 2-Tosylbenzoic Acid (CAS 860699-53-2)
- N-(3-Chloro-4-fluorophenyl)-3-methylbenzamide (CAS 346720-16-9)
- [3-(methylamino)oxolan-3-yl]methanol (CAS 1339578-61-8)
- 8-Bromo-Adenosine (CAS 2946-39-6)
- 5-Bromo-2-(phenylsulfonyl)-1H-indole (CAS 1505521-52-7)
- 2-Fluoro-6-isopropoxybenzoic acid (CAS 1369879-25-3)
- Benzyl (S)-3-(methylamino)pyrrolidine-1-carboxylate (CAS 1292324-49-2)
- 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)propan-2-ol (CAS 35987-38-3)
- Semaglutide Impurity 6 (CAS 62-57-7)
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