8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine CAS 478248-92-9
| CAS No. | 478248-92-9 |
| Molecular Formula | C8H3ClF5N3 |
| Molecular Weight | 271.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine.
CATO supplies 8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 478248-92-9), a certified reference material (molecular formula C8H3ClF5N3, MW 271.57 g/mol) for analytical method development and quality control.
8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (C8H3ClF5N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF5N3 |
| Molecular Weight | 271.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- (3-Chloro-4-(2-(diethylamino)ethoxy)phenyl)boronic acid (CAS 1704080-93-2)
- 2-Chloro-3,5-dinitro-6-(trifluoromethyl)pyridine (CAS 163238-99-1)
- 4-Chloro-5-methoxy-6-nitrobenzofuran-2-carboxylic acid (CAS 1441173-46-1)
- 2-Chloro-5-(3,4,5-trifluorobenzoyl)pyridine (CAS 1187165-43-0)
- 2-Chloro-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 1244039-65-3)
- 2-Chloro-4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 1269233-19-3)
- 5-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 1423706-66-4)
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Recommended Standards
- 4,4-(Chloromethylene)bis(chlorobenzene) (CAS 782-08-1)
- Clotrimazole Impurity 25 (CAS 3509-85-1)
- 3-(Chlorodifluoromethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 477871-29-7)
- Pentadecanoic-d29 Acid (CAS 130348-95-7)
- 2-[(2S)-5,5-dimethylmorpholin-2-yl]acetic acid (CAS 733717-87-8)
- 1-(3-(1H-Pyrazol-1-yl)pyrazin-2-yl)piperidin-4-amine (CAS 1708013-63-1)
- 2-({5-[3-(2,4-dichlorophenoxy)propyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-fluorophenyl)acetamide (CAS 882749-73-7)
- Tert-butyl (2,5-dimethyl-4-oxohexyl)carbamate (CAS 2018914-42-4)
- 4-Nonylphenol hexaethoxylate, mixture of nonylisomers (CAS 27177-01-1)
- 1-(tert-Butyl) 2-methyl (2R,4S)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylate (CAS 1610036-44-6)
- Edaravone impurity 35 (Mixture of Enantiomers) (CAS CATO-C4X-106235)
- [3,3'-Bipyrrolidine]-5,5'-dione (CAS 114601-41-1)
- 3-[4-(2-fluorophenyl)piperazin-1-yl]-3-oxopropanenitrile (CAS 379726-07-5)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
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