3-(3-Chlorophenyl)-4-((4-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione CAS 478255-03-7
| CAS No. | 478255-03-7 |
| Molecular Formula | C16H13ClN4O2S |
| Molecular Weight | 360.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(3-Chlorophenyl)-4-((4-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione.
3-(3-Chlorophenyl)-4-((4-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478255-03-7) is a high-purity analytical reference standard with the molecular formula C16H13ClN4O2S and a molecular weight of 360.82 g/mol.
Based on its molecular formula C16H13ClN4O2S, 3-(3-Chlorophenyl)-4-((4-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 360.82 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(3-Chlorophenyl)-4-((4-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13ClN4O2S |
| Molecular Weight | 360.82 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chlorophenyl Standards
- 2-{[3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]sulfanyl}acetohydrazide (CAS 133764-45-1)
- 2-{[4-(4-chlorophenyl)-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 893727-15-6)
- 3-(2-Chlorophenyl)-4-((2-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478253-84-8)
- 3-(2-Chlorophenyl)-4-((4-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-19-2)
- 3-(3-Chlorophenyl)-4-((2-hydroxy-3-methoxybenzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-64-7)
- N-(2-(2-(3-chlorophenyl)thiazol-4-yl)ethyl)-5-nitropyridin-2-amine (CAS 861207-09-2)
- N-(4-Chlorophenyl)-2-((3-(2-hydroxyphenyl)-1H-1,2,4-triazol-5-yl)thio)acetamide (CAS 332160-20-0)
- Ethyl 3-(4-(((3-chlorophenyl)amino)methyl)benzamido)propanoate (CAS 1624262-11-8)
Recommended Standards
- 4-(5-Chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-6-(methylsulfinyl)-1,3,5-triazin-2-amine (CAS 959763-01-0)
- N-(2-Chlorobenzyl)-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetamide (CAS 721406-24-2)
- 2-(3-(1H-pyrrol-1-yl)thiophene-2-carbonyl)-N-(4-chlorophenyl)hydrazine-1-carboxamide (CAS 478062-85-0)
- 2-(3-(1H-pyrrol-1-yl)thiophene-2-carbonyl)-N-(3-chlorophenyl)hydrazine-1-carboxamide (CAS 478062-86-1)
- 2-(4-(Benzyloxy)phenyl)-3-methylbutanoic acid (CAS 121108-85-8)
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- N-[2-(1H-indol-3-yl)ethyl]-4-(methylamino)butanamide hydrochloride (CAS 1568634-86-5)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
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