N-(3-chloro-4-methoxybenzyl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide CAS 478259-45-9
| CAS No. | 478259-45-9 |
| Molecular Formula | C19H16Cl2N2O3 |
| Molecular Weight | 391.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-(3-chloro-4-methoxybenzyl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-(3-chloro-4-methoxybenzyl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide (CAS 478259-45-9), molecular formula C19H16Cl2N2O3 and molecular weight 391.25 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(3-chloro-4-methoxybenzyl)-3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamide (C19H16Cl2N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C19H16Cl2N2O3 |
| Molecular Weight | 391.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
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- 2-chloro-3'-(4-methylpiperazinomethyl) benzophenone (CAS 898788-95-9)
- 2-(4-chloro-3-methylphenoxy)acetamide (CAS 7399-59-9)
- 3-chloro-4-({[(4-chlorobenzoyl)amino]carbonyl}amino)benzene-1-sulphonyl fluoride (CAS 284674-51-7)
- 1-(4-Chloro-3-fluoro-2-iodo-phenyl)-4-(trifluoromethyl)triazole (CAS 2097065-63-7)
- 5-Chloro-4-{[(4-methoxyphenyl)sulfanyl]methyl}-1-methyl-3-[(phenylsulfanyl)methyl]-1H-pyrazole (CAS 318248-74-7)
- 5-Chloro-N-(2,4-dimethoxyphenyl)-2-iodopyrimidin-4-amine (CAS 1704065-63-3)
Recommended Standards
- N-(2,4-Dichlorophenyl)-4-hydroxy-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxamide (CAS 300716-27-2)
- 1G-323S 320420-86-8 [(3Z)-1-[(4-chlorophenyl)methyl]-5-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino 3-chloropropanoate (CAS 320420-86-8)
- Bischloroanthrabenzoxocinone (CAS 866022-28-8)
- Doxapram Impurity 14 (CAS CATO-C4X-197314)
- 2-(5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)-5-(4-chlorophenyl)-1,3,4-oxadiazole (CAS 318256-03-0)
- N-(4-Bromo-3-(trifluoromethyl)phenyl)hydrazinecarbothioamide (CAS 1303993-77-2)
- (S)-tert-Butyl 3-((2-chloropyrimidin-4-yl)amino)pyrrolidine-1-carboxylate (CAS 1146159-96-7)
- 3,5-Dimethyl-2-propionylcyclohexan-1-one (CAS 1071674-23-1)
- 6-Bromo-4-oxochromane-2-carboxylic acid (CAS 440367-78-2)
- 1-(2,4-Dichloro-5-isopropoxyphenyl)-N-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 400736-19-8)
- Ethyl 5-methoxy-1H-pyrazole-3-carboxylate (CAS 180518-75-6)
- 2-methoxy-2-(oxolan-3-yl)ethan-1-amine (CAS 1467066-76-7)
- 1-(1H-Pyrazol-3-yl)cyclohexanol (CAS 23585-53-7)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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