Diosmin EP Impurity E CAS 480-36-4
| CAS No. | 480-36-4 |
| Molecular Formula | C28H32O14 |
| Molecular Weight | 592.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Diosmin EP Impurity E is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Diosmin EP Impurity E (CAS 480-36-4), a pharmacopoeial impurity reference standard (molecular formula C28H32O14, MW 592.55 g/mol) used for the identification and quantification of trace impurities in APIs.
Diosmin EP Impurity E (C28H32O14) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Diosmin EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H32O14 |
| Molecular Weight | 592.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Diosmin Standards
- Diosmin EP Impurity E-13C-d3 (Linarin-13C-d3) (CAS CATO-C4X-115614)
- Diosmin EP Impurity C-d4 (Isorhoifolin-d4) (CAS CATO-C4X-115613)
- Diosmin Impurity 8 (Mixture of Diastereomers) (CAS 108815-81-2)
- Diosmin EP Impurity C (CAS 552-57-8)
- Diosmin (CAS 520-27-4)
- Diosmin EP Impurity B (CAS 520-26-3)
- Diosmin-d3 (CAS CATO-C4X-115612)
- Diosmin Impurity 8 (CAS 28719-21-3)
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