Edoxaban Desmethyl Impurity HCl CAS 480449-52-3
| CAS No. | 480449-52-3 |
| Molecular Formula | C23H28ClN7O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Edoxaban Desmethyl Impurity HCl (CAS 480449-52-3), a pharmacopoeial impurity reference standard (molecular formula C23H28ClN7O4SHCl, MW 570.49 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Edoxaban Desmethyl Impurity HCl (C23H28ClN7O4SHCl) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H28ClN7O4S HCl |
| Molecular Weight | 570.49 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Edoxaban Standards
- Edoxaban Impurity 73 (CAS 1057651-37-2)
- Edoxaban Impurity 7 (CAS 1072-98-6)
- Edoxaban Impurity 71 (CAS 1093351-29-1)
- Edoxaban Impurity N8 HCl (CAS 1190971-73-3)
- Edoxaban Impurity 47 (CAS 1210348-16-5)
- Edoxaban Impurity 74 (CAS 1210348-21-2)
- Edoxaban Impurity 20 (CAS 1210348-34-7)
- Edoxaban Tosylate Monohydrate (CAS 1229194-11-9)
Recommended Standards
- Calcipotriol Impurity 23 (CAS 1630745-25-3)
- Dapagliflozin Impurity 87 (CAS CATO-C4X-113887)
- Sildenafil Impurity 287 (CAS CATO-C4X-1128287)
- (S)-3-(N-Boc-amino)-N-benzylsuccinimide 706780-18-9 (CAS 706780-18-9)
- 3,3,4,4,5,5,6,6,6-Nonafluorohexyl (4,4,5,5,5-pentafluoropentyl) carbonate (CAS 1980086-70-1)
- N,N-diallyl-4-aminobenzenesulfonamide (CAS 193891-96-2)
- Cyclobuta[g]quinoxaline (CAS 286390-29-2)
- 1-(3-Fluorobenzyl)-1h-imidazol-2-amine (CAS 1179962-33-4)
- Raloxifene-d4 HCl (CAS 1188263-47-9)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com