Edoxaban Impurity 3 CAS 480452-37-7
| CAS No. | 480452-37-7 |
| Molecular Formula | C16H22ClN5O3 |
| Molecular Weight | 367.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Edoxaban Impurity 3 (CAS 480452-37-7, C16H22ClN5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Edoxaban Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 367.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Edoxaban Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H22ClN5O3 |
| Molecular Weight | 367.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Edoxaban Standards
- Edoxaban Impurity 54 (CAS 482375-18-8)
- Edoxaban Impurity 12 (CAS 480450-71-3)
- Edoxaban Impurity 75 (CAS 1255529-31-7)
- Edoxaban Impurity N5 (CAS 365997-36-0)
- Edoxaban Impurity 28 (CAS 929693-31-2)
- Edoxaban Impurity 70 (CAS CATO-C4X-106370)
- Edoxaban Impurity 72 (CAS 365998-34-1)
- Edoxaban Impurity 32 (CAS 1461714-66-8)
Recommended Standards
- Prucalopride Impurity 48 (CAS 137211-63-3)
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- Piperazine Impurity 17 (CAS CATO-C4X-242717)
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- 4-Bromo-1-isopropyl-5-(methoxymethyl)-1H-pyrazole (CAS 1856088-55-5)
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- Neuropeptide Y (22-36) (CAS 119019-65-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com