8-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine CAS 481049-31-4

Description

The occurrence of 8-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

8-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine (CAS 481049-31-4) is a high-purity analytical reference standard with the molecular formula C13H8ClFN2 and a molecular weight of 246.67 g/mol.

The molecular framework of 8-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine (C13H8ClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 8-Chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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