Sitagliptin Impurity 99 CAS 486459-88-5
| CAS No. | 486459-88-5 |
| Molecular Formula | C16H16F5N5O |
| Molecular Weight | 389.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Sitagliptin Impurity 99 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Sitagliptin Impurity 99 (CAS 486459-88-5) is a certified pharmaceutical impurity reference standard with the molecular formula C16H16F5N5O and a molecular weight of 389.32 g/mol.
Structurally, Sitagliptin Impurity 99 (C16H16F5N5O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 389.32 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H16F5N5O |
| Molecular Weight | 389.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >80% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 75 (CAS 1334244-24-4)
- Sitagliptin Impurity 151 (CAS 1334244-32-4)
- Sitagliptin Impurity 152 (CAS CATO-C4X-1144152)
- Sitagliptin EP Impurity C (CAS 945261-48-3)
- Sitagliptin EP Impurity B (CAS 486460-31-5)
- Sitagliptin Impurity 86 (CAS 1246961-45-4)
- Sitagliptin Impurity 105 (CAS CATO-C4X-1144105)
- Sitagliptin Impurity 57 (CAS 1803026-58-5)
Recommended Standards
- trans-Heptachlor Epoxide Isomer A (CAS 28044-83-9)
- cis-Heptachlor Epoxide (CAS 1024-57-3)
- (R)-Ostarine (CAS 1132656-73-5)
- mk-2866,Ostarine (CAS 1202044-20-9)
- Ropinirole EP Impurity A (CAS 102842-51-3)
- Beclometasone Dipropionate Monohydrate EP Impurity D (CAS 52092-14-5)
- Pemafibrate Impurity 68 (CAS CATO-C4X-290368)
- 1-Ethyl-6-fluoro-2-methylquinolin-4(1H)-one (CAS 1209702-89-5)
- 3-Amino-N-(4-fluorophenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 496801-80-0)
- Milnacipran Impurity 16 (CAS 871100-19-5)
- N-(2,3-Difluorobenzyl)-1-(2,2-difluoroethyl)-1H-pyrazol-4-amine hydrochloride (CAS 1856051-99-4)
- N-((3-Benzamidophenyl)carbamothioyl)-3,4,5-trimethoxybenzamide (CAS 330829-30-6)
- 2-((Dimethylamino)((5-(trifluoromethyl)pyridin-2-yl)thio)methylene)malononitrile (CAS 339022-95-6)
- Anti-Inflammatory Peptide 2 (CAS 118850-72-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com