Sitagliptin Impurity 152 CAS CATO-C4X-1144152
| CAS No. | CATO-C4X-1144152 |
| Molecular Formula | C16H16F5N5O |
| Molecular Weight | 389.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Sitagliptin Impurity 152 (CAS CATO-C4X-1144152, C16H16F5N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sitagliptin Impurity 152 (C16H16F5N5O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H16F5N5O |
| Molecular Weight | 389.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 75 (CAS 1334244-24-4)
- Sitagliptin Impurity 151 (CAS 1334244-32-4)
- Sitagliptin EP Impurity C (CAS 945261-48-3)
- Sitagliptin EP Impurity B (CAS 486460-31-5)
- Sitagliptin Impurity 99 (CAS 486459-88-5)
- Sitagliptin Impurity 86 (CAS 1246961-45-4)
- Sitagliptin Impurity 105 (CAS CATO-C4X-1144105)
- Sitagliptin Impurity 57 (CAS 1803026-58-5)
Recommended Standards
- Heptachlor epoxide Impurity 4 (CAS 76986-14-6)
- 4-(2-Bromo-5-cyclohexyl-3-hydroxypent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol (CAS 60057-00-3)
- 10-[2-(trifluoromethyl)phenyl]-2,3,7,10-tetrahydro[1,4]dioxino[2,3-g]furo[3,4-b]quinolin-9(6H)-one (CAS 882747-25-3)
- trans-Heptachlor Epoxide Isomer A (CAS 28044-83-9)
- Clemastine Impurity 30 (CAS CATO-C4X-183730)
- Enoxacin Impurity 4 (CAS 87939-21-7)
- Selumetinib Impurity 10 (CAS CATO-C4X-305310)
- 4-{[2-(4-methylphenyl)-2-oxoethyl]amino}butanoic acid hydrochloride (CAS 1193389-37-5)
- 5-(4-Chlorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1493953-92-6)
- 4-(5-((2-Chloro-6-fluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 521281-98-1)
- 1-(6-Hydroxy-2,3-dimethoxyphenyl)ethanone (CAS 22248-13-1)
- ((2R,3S,5R)-3-Hydroxy-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 53696-69-8)
- 4-MEthanesulfonyl-1,2-dihydroisoquinolin-1-one (CAS 1820664-84-3)
- Liraglutide-d8 Tritrifluoroacetate (CAS CATO-C4X-199223)
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