Rosuvastatin Impurity 78 CAS 488798-37-4
| CAS No. | 488798-37-4 |
| Molecular Formula | C15H15FN2O3 |
| Molecular Weight | 290.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Rosuvastatin Impurity 78 (C15H15FN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Rosuvastatin Impurity 78 (CAS 488798-37-4, C15H15FN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H15FN2O3 |
| Molecular Weight | 290.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 269 (CAS CATO-C4X-1169269)
- Rosuvastatin Impurity 79 (CAS 488798-36-3)
- Rosuvastatin Impurity 247 (CAS CATO-C4X-1169247)
- Rosuvastatin Impurity 154 (CAS 154026-94-5)
- Rosuvastatin Impurity 254 (CAS 521974-01-6)
- Rosuvastatin Impurity 86 (CAS 521973-99-9)
- Rosuvastatin Impurity 95 (CAS CATO-C4X-116995)
- Rosuvastatin Impurity 96 (CAS 521974-00-5)
Recommended Standards
- 953752-71-1 N-(4-Amino-2-methoxyphenyl)-2-(3-fluorophenoxy)-acetamide (CAS 953752-71-1)
- Cefazedone Impurity 14 (CAS 57457-59-7)
- N-(5-amino-2-methoxyphenyl)-2-(3-fluorophenoxy)acetamide (CAS 953896-36-1)
- Flurbiprofen Impurity 111 (CAS CATO-C4X-1444111)
- Bedaquiline Impurity 26 (CAS 654654-19-0)
- Carteolol Impurity 20 (CAS CATO-C4X-228720)
- Everolimus Impurity 27 (CAS CATO-C4X-112227)
- Ethyl Ferulate (CAS 4046-02-0)
- 16-Phosphonohexadecanoic acid (CAS 443361-18-0)
- 2-Bromo-9-phenyl-9H-fluoren-9-ol (CAS 736928-22-6)
- 2-Ethoxy-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1334167-86-0)
- 948862-50-8 16:1 aldehyde-d5 (CAS 948862-50-8)
- (S)-(-)-2-amino-3-methyl-1,1-diphenylbutane (CAS 233772-37-7)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com