Sertraline EP Impurity A CAS 79836-45-6
| CAS No. | 79836-45-6 |
| Molecular Formula | C17H17Cl2N |
| Molecular Weight | 306.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sertraline EP Impurity A.
Sertraline EP Impurity A (CAS 79836-45-6) is a certified pharmaceutical impurity reference standard with the molecular formula C17H17Cl2N and a molecular weight of 306.23 g/mol.
Sertraline EP Impurity A (C17H17Cl2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17Cl2N |
| Molecular Weight | 306.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline Impurity C49 (CAS 140631-53-4)
- Sertraline EP Impurity G (CAS 79617-98-4)
- Sertraline Impurity 53 (CAS 2184053-08-3)
- Sertraline (CAS 79617-96-2)
- Sertraline oxime Impurity (CAS 152642-35-8)
- Sertraline Impurity 64 (CAS 79560-20-6)
- Sertraline Impurity 51 (CAS CATO-C4X-134451)
- Sertraline-13C-15N-d3 (CAS CATO-C4X-13449)
Recommended Standards
- tert-Butyl (4-nitro-3-(trifluoromethyl)phenyl)carbamate (CAS 1043962-48-6)
- 5-Nitro-1-(2-(trifluoromethyl)phenyl)-1H-indole (CAS 1060803-41-9)
- Terbinafine Impurity 31 (CAS CATO-C4X-133831)
- tert-Butyl ((1r,4r)-4-(2-bromoethyl)cyclohexyl)carbamate (CAS 1062468-06-7)
- Formoterol impurity 133 (CAS CATO-C4X-1525133)
- Roxadustat Impurity 162 (CAS CATO-C4X-2213162)
- Tirofiban Impurity 33 (CAS 16870-43-2)
- Lusutrombopag Impurity 53 (CAS CATO-C4X-208453)
- Ethyl N-Boc-2-piperidineacetate (CAS 118667-62-2)
- (1-(Cyclopropylmethyl)-1H-imidazol-5-yl)methanamine (CAS 1468941-24-3)
- Obeticholic Acid Impurity 46 (CAS 2241648-47-3)
- N-Nitrosomorpholine-d8 (CAS 1219805-76-1)
- 3-Methoxy-6-phenyl-1,2,4-triazin-5(4H)-one (CAS 37526-36-6)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
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