Sulindac EP Impurity C CAS 49627-27-2
| CAS No. | 49627-27-2 |
| Molecular Formula | C20H17FO2S |
| Molecular Weight | 340.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Sulindac EP Impurity C (CAS 49627-27-2) is a certified pharmaceutical impurity reference standard with the molecular formula C20H17FO2S and a molecular weight of 340.41 g/mol.
Owing to a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, Sulindac EP Impurity C is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 340.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H17FO2S |
| Molecular Weight | 340.41 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Sulindac Standards
- Sulindac EP Impurity C (CAS 32004-67-4)
- Sulindac impurity 15 (CAS CATO-C4X-293015)
- Sulindac Impurity 8 (CAS 61812-45-1)
- Sulindac EP Impurity C-d3 (CAS 250608-66-3)
- Sulindac Sulfide-d7 (CAS CATO-C4X-293018)
- (S)-Sulindac (CAS 149116-77-8)
- (R)-Sulindac (CAS 190967-68-1)
- Sulindac Impurity 16 (CAS CATO-C4X-293016)
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