Lenvatinib Impurity 88 CAS CATO-C4X-114088
| CAS No. | CATO-C4X-114088 |
| Molecular Formula | C24H18Cl2N4O5 |
| Molecular Weight | 513.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lenvatinib Impurity 88.
As a process- or degradation-related impurity, Lenvatinib Impurity 88 (CAS CATO-C4X-114088, C24H18Cl2N4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lenvatinib Impurity 88 (C24H18Cl2N4O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H18Cl2N4O5 |
| Molecular Weight | 513.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Lenvatinib Standards
- Lenvatinib Impurity 145 (CAS CATO-C4X-1140145)
- Lenvatinib Impurity 184 (CAS 2412398-76-4)
- Lenvatinib Impurity 93 (CAS CATO-C4X-114093)
- Lenvatinib Impurity 158 (CAS CATO-C4X-1140158)
- Lenvatinib Impurity 181 (CAS CATO-C4X-1140181)
- Lenvatinib Impurity 182 (CAS CATO-C4X-1140182)
- Lenvatinib Impurity 157 (CAS CATO-C4X-1140157)
- Lenvatinib Impurity 67 (CAS 2380197-90-8)
Recommended Standards
- 4-(4-Chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide (CAS 874119-56-9)
- Crisaborole lmpurity 85 (CAS CATO-C4X-202185)
- Fmoc-p-iodo-Phe-OH (CAS 82565-68-2)
- Deflazacort Impurity 92 (CAS CATO-C4X-202192)
- Cenobamate Impurity 32 (CAS CATO-C4X-241632)
- Upadacitinib Impurity 174 (CAS CATO-C4X-2405174)
- Ambroxol Impurity 88 (CAS CATO-C4X-108588)
- 3-Chloropyridazin-4-ol (CAS 1379240-74-0)
- 1-Chloro-4-(2-chloroethanesulfinyl)benzene (CAS 1170637-69-0)
- Ethyl 2-(1-methyl-1H-imidazol-4-yl)acetate (CAS 916792-95-5)
- N'2-(2-chloroacetyl)-3-chloro-5-(trifluoromethyl)pyridine-2-carbohydrazide (CAS 246862-66-8)
- 2-((1-Cyclohexylethyl)amino)-N,N-dimethylacetamide (CAS 1157911-14-2)
- 2-(quinoxalin-2-yl)ethan-1-amine (CAS 500727-73-1)
- Des-Pro36-37-Tirzepatide (CAS CATO-CPTD788938)
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