4-{4-Methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine CAS 499795-87-8
| CAS No. | 499795-87-8 |
| Molecular Formula | C15H11F3N4S |
| Molecular Weight | 336.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-{4-Methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499795-87-8), molecular formula C15H11F3N4S and molecular weight 336.33 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-{4-Methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (C15H11F3N4S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-{4-Methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H11F3N4S |
| Molecular Weight | 336.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- (2E)-2-({[3-(trifluoromethyl)phenyl]amino}methylidene)-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 478042-63-6)
- [1-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexan-4-yl]methyl 4-methylbenzenesulfonate (CAS 2770347-99-2)
- 1-((2-(Trifluoromethyl)phenyl)sulfonyl)piperidine-4-carboxamide (CAS 878909-79-6)
- 2-Phenyl-5-({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)-1,3,4-oxadiazole (CAS 477846-61-0)
- 4-(2-(Trifluoromethyl)benzyl)tetrahydro-2h-thiopyran-4-carboxylic acid 1,1-dioxide (CAS 2197052-41-6)
- 4-(3-(Trifluoromethyl)benzyl)tetrahydro-2h-thiopyran-4-carboxylic acid 1,1-dioxide (CAS 2197062-13-6)
- 4-(4-(Trifluoromethyl)benzyl)tetrahydro-2h-thiopyran-4-carboxylic acid 1,1-dioxide (CAS 2197056-70-3)
- 4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499796-52-0)
Recommended Standards
- 4-(Benzyloxy)cyclohex-1-en-1-yl trifluoromethanesulfonate (CAS 317831-30-4)
- 5-[2-(Methylsulfanyl)phenyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (CAS 339015-63-3)
- 5-[2-(Methylsulfanyl)phenyl]-3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (CAS 339099-65-9)
- 6-((3-(Trifluoromethyl)phenyl)thio)quinazoline-2,4-diamine (CAS 51123-99-0)
- 2-Bromo-5-methoxy-N-(2-(thiophen-3-yl)benzyl)benzamide (CAS 1796947-13-1)
- 4-Chloro-2-ethynyl-1-methylbenzene (CAS 74331-72-9)
- 1-(2-Chloro-5-methylthiophen-3-yl)-2-phenylethanone (CAS 1823392-42-2)
- 1-(1-Methyl-3-phenyl-5-(p-tolylthio)-1H-pyrazol-4-yl)hept-2-yn-1-ol (CAS 318949-13-2)
- Cabotegravir Impurity 8 (CAS 1616340-68-1)
- 4-(chloromethyl)-2-(2-methoxyphenyl)pyrimidine (CAS 1343346-38-2)
- 2-(2-Methoxy-5-methyl-3-nitrophenyl)-2H-benzo[d][1,2,3]triazole (CAS 122652-15-7)
- 3-(3-Chloro-4-methoxyphenyl)-3-phenylpropanoic acid (CAS 946055-58-9)
- 2-(3-Amino-1h-pyrazol-1-yl)-N-(methylcarbamoyl)propanamide (CAS 1178626-58-8)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
Why CATO?
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