Hydrocortisone EP Impurity A CAS 50-24-8
| CAS No. | 50-24-8 |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 360.44 g/mol gives Hydrocortisone EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Hydrocortisone EP Impurity A (CAS 50-24-8, C21H28O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Hydrocortisone EP Impurity A (C21H28O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Hydrocortisone Standards
- Hydrocortisone (9beta,11beta)-Epoxide (CAS 10072-97-6)
- Hydrocortisone EP Impurity E (CAS 600-99-7)
- Hydrocortisone EP Impurity G (CAS 14760-49-7)
- Hydrocortisone Degradation ProductDISCONTINUED. Offer D229160 (CAS 1960421-03-7)
- Hydrocortisone Impurity 18 (CAS 27149-68-4)
- Hydrocortisone EP Impurity M (CAS 566-35-8)
- Hydrocortisone Impurity 53 (CAS 80753-80-6)
- Hydrocortisone Impurity 56 (CAS CATO-C4X-140156)
Recommended Standards
- Metoprolol Impurity 19 (CAS 230975-30-1)
- (2R,3S)-3-(3-HYDROXYPROPOXY)-1,4-BIS(PHENYLMETHOXY)-2-BUTANOL 200636-15-3 (CAS 200636-15-3)
- Prednisolone Impurity 37 (CAS 307518-72-5)
- Prednisone Impurity 16 (CAS 15714-29-1)
- Pemetrexed EP Impurity C (CAS 1802552-16-4)
- Nifedipine Impurity 26 (CAS 41867-20-3)
- Tenofovir Alafenamide Impurity 4 (CAS CATO-C4X-17974)
- Methyl 2-methyl-4-(3-methyl-1h-pyrazol-1-yl)-2-(methylamino)butanoate (CAS 1339547-27-1)
- 3-[3-(propan-2-yloxy)phenyl]prop-2-enoic acid (CAS 58420-22-7)
- Goserelin BP Impurity 9 Trifluoroacetic Acid (CAS CATO-C4X-192031)
- N-hydroxy-3-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)propanimidamide (CAS 1006334-31-1)
- Varenicline Impurity 58 (CAS CATO-C4X-196258)
- 5-Bromo-2-(methoxycarbonylamino)pyridine (CAS 207922-56-3)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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