Metoprolol Impurity 19 CAS 230975-30-1
| CAS No. | 230975-30-1 |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Metoprolol Impurity 19 (CAS 230975-30-1, C21H28O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Metoprolol Impurity 19 (C21H28O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Metoprolol Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
Related Metoprolol Standards
- Metoprolol Impurity 33 (CAS CATO-C4X-136733)
- Metoprolol Impurity 34 (CAS CATO-C4X-136734)
- Metoprolol Impurity 35 (CAS CATO-C4X-136735)
- Metoprolol Impurity 46 (CAS CATO-C4X-136746)
- Metoprolol EP Impurity J (CAS 163685-37-8)
- Metoprolol Impurity 52 (CAS CATO-C4X-136752)
- Metoprolol Impurity 49 (CAS CATO-C4X-136749)
- Metoprolol Impurity 48 (CAS CATO-C4X-136748)
Recommended Standards
- (2R,3S)-3-(3-HYDROXYPROPOXY)-1,4-BIS(PHENYLMETHOXY)-2-BUTANOL 200636-15-3 (CAS 200636-15-3)
- Hydrocortisone EP Impurity A (CAS 50-24-8)
- Prednisolone Impurity 37 (CAS 307518-72-5)
- Hydrocortisone EP Impurity E (CAS 600-99-7)
- Dequalinium impurity 19 (CAS CATO-C4X-193619)
- Esomeprazole Impurity 48 (CAS CATO-C4X-111248)
- N-Nitroso Nerandomilast impurity 1 (CAS CATO-C4X-34731)
- 1-(2-Chlorobenzyl)-3-(4-nitrobenzyl)imidazolidine-2,4,5-trione (CAS 341967-17-7)
- (S)-2-methoxy-1-(2-(trifluoromethyl)phenyl)ethan-1-amine (CAS 1269929-62-5)
- 4-(Methylamino)-3-nitrobenzoyl chloride (CAS 82357-48-0)
- Mitomycin impurity 4 (CAS CATO-C4X-17014)
- [His]1+12-Semaglutide (CAS CATO-C4X-2226178)
- 7-(6-Methoxypyridazin-3-yl)-1-methyl-1,7-diazaspiro[4.4]nonane (CAS 646056-35-1)
- [D-Phe22]Semaglutide (CAS CATO-C4X-2226222)
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