Hydrocortisone EP Impurity E CAS 600-99-7
| CAS No. | 600-99-7 |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydrocortisone EP Impurity E.
As a process- or degradation-related impurity, Hydrocortisone EP Impurity E (CAS 600-99-7, C21H28O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Hydrocortisone EP Impurity E (C21H28O5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Hydrocortisone Standards
- Hydrocortisone (9beta,11beta)-Epoxide (CAS 10072-97-6)
- Hydrocortisone EP Impurity A (CAS 50-24-8)
- Hydrocortisone EP Impurity G (CAS 14760-49-7)
- Hydrocortisone Degradation ProductDISCONTINUED. Offer D229160 (CAS 1960421-03-7)
- Hydrocortisone Impurity 18 (CAS 27149-68-4)
- Hydrocortisone EP Impurity M (CAS 566-35-8)
- Hydrocortisone Impurity 53 (CAS 80753-80-6)
- Hydrocortisone Impurity 56 (CAS CATO-C4X-140156)
Recommended Standards
- Metoprolol Impurity 19 (CAS 230975-30-1)
- Prednisone Impurity 16 (CAS 15714-29-1)
- (2R,3S)-3-(3-HYDROXYPROPOXY)-1,4-BIS(PHENYLMETHOXY)-2-BUTANOL 200636-15-3 (CAS 200636-15-3)
- Prednisolone Impurity 43 (CAS 905-52-2)
- Atrasentan Impurity 105 (CAS 1059052-12-8)
- Valsartan Impurity 6 HCl (CAS 1266616-11-8)
- BPA Impurity 5 (CAS CATO-C4X-31395)
- 3,4-Dihydro-2(1H)-isoquinolinyl(3-piperidinyl)-methanone hydrochloride (CAS 1220034-95-6)
- Mirogabalin Impurity 115 (CAS CATO-C4X-2924115)
- 5-Bromo-4-methyl-2-phenylthiazole (CAS 28771-82-6)
- 2-(4-Amino-3-fluorophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (CAS 1355338-16-7)
- Methyl 3-iodo-1H-pyrrolo[3,2-b]pyridine-7-carboxylate (CAS 2173991-55-2)
- 1-methyl-1,3-diazinane-2-thione (CAS 24421-05-4)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
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