Ixazomib Impurity 31 CAS 50-73-7
| CAS No. | 50-73-7 |
| Molecular Formula | C7H3Cl3O2 |
| Molecular Weight | 225.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Ixazomib Impurity 31 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 225.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Ixazomib Impurity 31 (CAS 50-73-7, C7H3Cl3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3Cl3O2 |
| Molecular Weight | 225.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Ixazomib Standards
Recommended Standards
- 3,5-Dichloro-4-hydroxybenzoyl chloride (CAS 59595-92-5)
- 3,5,6-Trichlorosalicylaldehyde (CAS 23602-65-5)
- 3,4-Dichlorophenyl chloroformate (CAS 72305-24-9)
- 3,4,5-Trichloropicolinamide (CAS 202192-84-5)
- Deucravacitinib Impurity 18 (CAS 1609392-27-9)
- Lemborexant impurity 02 (CAS 1369769-35-6)
- Daprodustat Impurity 15 (CAS 65461-92-9)
- 3-Bromo-2-chloro-6-methyl-4-nitropyridine (CAS 1805519-08-7)
- n-(3-Bromobenzyl)-1-methoxypropan-2-amine (CAS 355815-55-3)
- 3-[(2-Methoxy-4-propylphenoxy)methyl]piperidinehydrochloride (CAS 1220034-78-5)
- 1-Bromo-4-((hexyloxy)methyl)benzene (CAS 153407-07-9)
- 5-(3-Bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine (CAS 214697-26-4)
- 5-Bromo-7-methyl-2,3-dihydro-1H-inden-4-ol (CAS 175136-06-8)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
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