Ixazomib Impurity 65 CAS 50-74-8
| CAS No. | 50-74-8 |
| Molecular Formula | C7H2Cl4O2 |
| Molecular Weight | 259.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ixazomib Impurity 65.
As a process- or degradation-related impurity, Ixazomib Impurity 65 (CAS 50-74-8, C7H2Cl4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ixazomib Impurity 65 (C7H2Cl4O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ixazomib Impurity 65 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H2Cl4O2 |
| Molecular Weight | 259.90 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Ixazomib Standards
- Ixazomib Impurity 66 (CAS 50-38-4)
- Ixazomib Impurity 45 (CAS CATO-C4X-126745)
- Ixazomib Impurity 10 (CAS 667403-46-5)
- Ixazomib Impurity 9 (CAS 1378314-08-9)
- Ixazomib Impurity 80 (CAS CATO-C4X-126780)
- Ixazomib Impurity 61 (CAS CATO-C4X-126761)
- Ixazomib Impurity 69 (CAS 121-48-2)
- Ixazomib Impurity 21 (CAS CATO-C4X-126721)
Recommended Standards
- 5-Fluoro-2-(trimethylstannyl)pyridine (CAS 453568-60-0)
- 2-Fluoro-5-(trimethylstannyl)pyridine (CAS 660847-68-7)
- 2,3-Dibromopentanoic acid (CAS 139185-84-5)
- 2,4,6-Trichlorophenyl chloroformate (CAS 4511-19-7)
- Ketoprofen Impurity 86 (CAS CATO-C4X-147186)
- Naltrexone impurity 60 (CAS CATO-C4X-147560)
- Capivasertib Impurity 5 (CAS CATO-C4X-33125)
- Methyl 3-[(5-nitropyridin-2-yl)thio]propanoate (CAS 176658-24-5)
- Methyl (2,2,2-trifluoroacetyl)-L-valinate (CAS 1463-21-4)
- 4-Chloro-6-(1H-pyrazol-1-yl)pyrimidin-5-amine (CAS 1342392-11-3)
- 1-(2-(2-(1H-Pyrazol-1-yl)thiazol-4-yl)ethyl)-3-(4-fluorobenzyl)urea (CAS 1428372-19-3)
- N-(3,5-bis(trifluoromethyl)phenyl)-2-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetamide (CAS 556787-47-4)
- tert-Butyl N-[2-(4-methoxyphenyl)-2-oxoethyl]carbamate (CAS 778617-61-1)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com