Metoclopramide EP Impurity H CAS 50-86-2
| CAS No. | 50-86-2 |
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Metoclopramide EP Impurity H.
Metoclopramide EP Impurity H (CAS 50-86-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9NO4 and a molecular weight of 195.17 g/mol.
Metoclopramide EP Impurity H (C9H9NO4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Metoclopramide EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Metoclopramide Standards
- Metoclopramide Impurity 85 (CAS 1882-76-4)
- Metoclopramide Impurity 45 (CAS CATO-C4X-141545)
- Metoclopramide Impurity 1 (CAS 24190-74-7)
- Metoclopramide Impurity 18 (CAS 58590-42-4)
- Metoclopramide EP Impurity C (CAS 7206-70-4)
- Metoclopramide Impurity 14 (CAS CATO-C4X-141514)
- Metoclopramide Impurity 24 (CAS 55304-05-7)
- Metoclopramide Impurity 37 (CAS 184151-07-3)
Recommended Standards
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- Vonoprazan Impurity 221 HCl (CAS 1978371-23-1 (free base))
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- N-ethyl-4-phenylcyclohexan-1-amine (CAS 1017020-39-1)
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