Metoclopramide Impurity 14 CAS CATO-C4X-141514
| CAS No. | CATO-C4X-141514 |
| Molecular Formula | C7H7ClN2O2 |
| Molecular Weight | 186.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Metoclopramide Impurity 14 (CAS CATO-C4X-141514, C7H7ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Metoclopramide Impurity 14 (C7H7ClN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN2O2 |
| Molecular Weight | 186.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Metoclopramide Standards
- Metoclopramide EP Impurity H (CAS 50-86-2)
- Metoclopramide Impurity 85 (CAS 1882-76-4)
- Metoclopramide Impurity 45 (CAS CATO-C4X-141545)
- Metoclopramide Impurity 1 (CAS 24190-74-7)
- Metoclopramide Impurity 18 (CAS 58590-42-4)
- Metoclopramide EP Impurity C (CAS 7206-70-4)
- Metoclopramide Impurity 24 (CAS 55304-05-7)
- Metoclopramide Impurity 37 (CAS 184151-07-3)
Recommended Standards
- Lenvatinib Impurity 142 (CAS 1069122-99-1)
- Minoxidil Impurity 24 (CAS CATO-C4X-170024)
- Lansoprazole Impurity 50 (CAS 116418-99-6)
- Lodoxamide lmpurity 12 (CAS 69236-82-4)
- Cephalexin Impurity 41 (CAS CATO-C4X-126141)
- Trazodone impurity 78 (CAS 1799917-53-5（free base）)
- Lumateperone Impurity 3 (CAS CATO-C4X-22013)
- 1-(3-Nitrophenyl)cyclopentane-1-carbonitrile (CAS 1067192-37-3)
- Suzetrigine Impurity 14 (CAS CATO-C4X-336914)
- 2-(3-(Bromomethyl)piperidin-1-yl)pyrimidine (CAS 1353947-69-9)
- 1220036-52-1 2-Amino-1-[3,4-dihydro-2(1H)-isoquinolinyl]-1-ethanone hydrochloride 2305AD C11H15ClN2O (CAS 1220036-52-1)
- Potassium 2,5-dimethylthiophene-3-trifluoroborate (CAS 1294455-24-5)
- Tris(acetonitrile)tricarbonyltungsten(0) (CAS 16800-47-8)
- Semaglutide impurity 66 (CAS CATO-C4X-222666)
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