Mesalazine Impurity 21 CAS 51-59-2
| CAS No. | 51-59-2 |
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 195.17 g/mol gives Mesalazine Impurity 21 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Mesalazine Impurity 21 (CAS 51-59-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9NO4 and a molecular weight of 195.17 g/mol.
Mesalazine Impurity 21 (C9H9NO4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Mesalazine Standards
- Mesalazine Impurity 24 (CAS 859964-08-2)
- Mesalazine Impurity 2 (CAS 26537-19-9)
- Mesalazine Impurity 26 (CAS 1689-82-3)
- Mesalazine Impurity 27 (CAS 2362-57-4)
- Mesalazine Impurity 29 (CAS 2437-11-8)
- Mesalazine EP Impurity M (CAS 2516-96-3)
- Mesalazine EP Impurity Q (CAS 3970-35-2)
- Mesalazine Impurity 46 (CAS 34662-36-7)
Recommended Standards
- Ticagrelor Impurity 135 (CAS CATO-C4X-1093135)
- Telmisartan Impurity 52 (CAS 7356-11-8)
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- Metoclopramide EP Impurity H (CAS 50-86-2)
- Promethazine Impurity 72 (CAS 409314-72-3)
- Ceftazidime EP Impurity G (CAS 194241-83-3)
- Felodipine Impurity 31 (CAS CATO-C4X-109431)
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- 6-(2-Mercaptoacetamido)-N-(quinolin-6-yl)hexanamide (CAS 828920-15-6)
- Imatinib Impurity 91 (CAS CATO-C4X-106891)
- (2,3,9,10,16,17,23,24-Octaaminophthalocyaninato)nickel(II) (CAS 455284-10-3)
- 4-(4-Methyl-1H-indazol-1-yl)-4-oxobutanoic acid (CAS 902937-33-1)
- Hexapeptide-9 (CAS 1228371-11-6)
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