3-(2,5-Difluorophenyl)isoxazol-5-amine CAS 501116-34-3
| CAS No. | 501116-34-3 |
| Molecular Formula | C9H6F2N2O |
| Molecular Weight | 196.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
3-(2,5-Difluorophenyl)isoxazol-5-amine (CAS 501116-34-3) is a high-purity analytical reference standard with the molecular formula C9H6F2N2O and a molecular weight of 196.15 g/mol.
The molecular framework of 3-(2,5-Difluorophenyl)isoxazol-5-amine (C9H6F2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H6F2N2O |
| Molecular Weight | 196.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorophenyl Standards
- 3-(3,5-difluorophenyl)-1,2-oxazol-5-amine (CAS 1020996-82-0)
- 4-(3,4-Difluorophenyl)oxazol-2-amine (CAS 1247569-55-6)
- 4-(2,6-Difluorophenyl)-1,3-oxazol-2-amine (CAS 1249863-38-4)
- 5-(2,5-Difluorophenyl)isoxazol-3-amine (CAS 1267143-12-3)
- 5-(3,4-Difluorophenyl)isoxazol-3-amine (CAS 1268090-93-2)
- Methyl 3-(3,4-difluorophenyl)propiolate (CAS 1341988-80-4)
- Methyl 3-(2,6-difluorophenyl)prop-2-ynoate (CAS 1342445-09-3)
- 4-(2,4-Difluorophenyl)-1,2-oxazol-5-amine (CAS 1342450-56-9)
Recommended Standards
- 2-Cyano-N-(3,4-difluorophenyl)acetamide (CAS 541519-41-9)
- 3-(3,4-Difluorophenyl)isoxazol-5-amine (CAS 874376-50-8)
- 2-Cyano-N-(2,5-difluorophenyl)acetamide (CAS 87165-17-1)
- 3-(Trifluoromethyl)thiophene-2-carboxylic Acid (CAS 767337-59-7)
- 3-(2-Fluorophenyl)morpholine (CAS 1017418-51-7)
- Benzyl 2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetate (CAS 896376-66-2)
- n1,n1-Diethyl-n2-((5-methylthiophen-2-yl)methyl)ethane-1,2-diamine (CAS 880811-99-4)
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