Liothyronine EP Impurity A CAS 51-48-9
| CAS No. | 51-48-9 |
| Molecular Formula | C15H11I4NO4 |
| Molecular Weight | 776.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Liothyronine EP Impurity A (CAS 51-48-9) is a certified pharmaceutical impurity reference standard with the molecular formula C15H11I4NO4 and a molecular weight of 776.87 g/mol.
Liothyronine EP Impurity A (C15H11I4NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H11I4NO4 |
| Molecular Weight | 776.87 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Liothyronine Standards
- Liothyronine EP Impurity A-13C9-15N (CAS 1431868-11-9)
- Liothyronine Impurity 2 (CAS 1217733-23-7)
- rac-Liothyronine-15N-13C9 (CAS CATO-C4X-21313)
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- Liothyronine Impurity N1 (CAS 92151-30-9)
- Liothyronine Impurity 5 (CAS 4299-64-3)
- Liothyronine Impurity 4 (CAS CATO-C4X-21314)
- Liothyronine EP Impurity B (CAS 300-39-0)
Recommended Standards
- SKM 4-45-1 (CAS 290374-09-3)
- DL-Thyroxine (CAS 300-30-1)
- Cefetamet Impurity 6 (CAS CATO-C4X-12876)
- D-Thyroxine (CAS 51-49-0)
- Cefixime polymer impurity 1 (CAS CATO-C4X-113957)
- Ceftolozane Impurity 29 (CAS CATO-C4X-240629)
- Cefminox Impurity 31 (CAS CATO-C4X-192631)
- Morphine Sulfate Related Compound B CII (Pseudomorphine) (1448027) (CAS 125-24-6)
- 2-chloro-3-hydrazinyl-5,6-dimethylpyrazine (CAS 1423034-19-8)
- 1-(6-Ethoxy-4-methylquinazolin-2-yl)guanidine (CAS 5361-35-3)
- 4-(2-Chloro-5-methylphenoxy)-3-methylphenylamine (CAS 946741-79-3)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-iodobenzoic acid (CAS 2243513-28-0)
- N-(2-Methoxy-5-nitrophenyl)-2-(morpholin-4-yl)acetamide (CAS 882749-42-0)
- Palmitoyl Tetrapeptide-7 (CAS 221227-05-0)
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