Liothyronine Impurity N1 CAS 92151-30-9
| CAS No. | 92151-30-9 |
| Molecular Formula | C14H9I3O4 |
| Molecular Weight | 621.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Liothyronine Impurity N1 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Liothyronine Impurity N1 (CAS 92151-30-9), a pharmacopoeial impurity reference standard (molecular formula C14H9I3O4, MW 621.93 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, a polycyclic aromatic system, Liothyronine Impurity N1 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 621.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9I3O4 |
| Molecular Weight | 621.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | I-containing |
Related Liothyronine Standards
- Liothyronine Impurity 5 (CAS 4299-64-3)
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- rac-Liothyronine-15N-13C9 (CAS CATO-C4X-21313)
- Liothyronine Impurity 2 (CAS 1217733-23-7)
- Liothyronine EP Impurity A (CAS 51-48-9)
- Liothyronine EP Impurity A-13C9-15N (CAS 1431868-11-9)
- Liothyronine EP Impurity B (CAS 300-39-0)
- Liothyronine Impurity 2 (CAS 70-78-0)
Recommended Standards
- O,o-bis(4-bromo-2,5-dichlorophenyl) phenylphosphonothioate (CAS 50654-88-1)
- Levothyroxine EP Impurity C (CAS 51-24-1)
- 1,2-di-o-tridecyl-sn-glycero-3-phosphocholine 328250-31-3 (CAS 328250-31-3)
- Hydrochlorothiazide Impurity 28 (CAS CATO-C4X-117728)
- Aripiprazole Impurity N3 (CAS 771-19-7)
- Resmetirom impurity 72 (CAS 1581304-51-9)
- Hyoscine Butylbromide EP Impurity C Bromide (CAS 155-41-9)
- N-(4-ethylphenyl)-N-[(5-methylthien-2-yl)methyl]amine (CAS 869947-61-5)
- Potassium trifluoro((isopropylamino)methyl)borate (CAS 1705578-42-2)
- 4-BEC Hydrochloride (1.0mg/ml in Acetonitrile) (CAS 135333-26-5)
- 6,8-Dibromo-1H-benzo[d][1,3]oxazine-2,4-dione (CAS 54754-60-8)
- Indometacin Impurity 18 (CAS 75511-23-8)
- Methyl 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylate (CAS 852021-86-4)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
Why CATO?
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