Liothyronine EP Impurity B CAS 300-39-0
| CAS No. | 300-39-0 |
| Molecular Formula | C9H9I2NO3 |
| Molecular Weight | 432.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Liothyronine EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Liothyronine EP Impurity B (CAS 300-39-0, C9H9I2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H9I2NO3, Liothyronine EP Impurity B contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 432.98 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H9I2NO3 |
| Molecular Weight | 432.98 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Liothyronine Standards
- Liothyronine Impurity 2 (CAS 70-78-0)
- Liothyronine Impurity 5 (CAS 4299-64-3)
- Liothyronine Impurity N1 (CAS 92151-30-9)
- Liothyronine related impurity, (R)-2-amino (CAS 5714-08-9)
- rac-Liothyronine-15N-13C9 (CAS CATO-C4X-21313)
- Liothyronine Impurity 2 (CAS 1217733-23-7)
- Liothyronine EP Impurity A (CAS 51-48-9)
- Liothyronine EP Impurity A-13C9-15N (CAS 1431868-11-9)
Recommended Standards
- Clobetasol Propionate EP Impurity E (CAS CATO-C4X-159214)
- Luliconazole Impurity 12 (CAS CATO-C4X-285312)
- 3-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid (CAS 3734-24-5)
- 4-Bromo-6-fluoro-2-(3-iodophenyl)-2H-benzo[d][1,2,3]triazol-5-amine (CAS 1706459-02-0)
- Apremilast Impurity 121 (CAS CATO-C4X-1009121)
- Anastrozole Impurity 39 (CAS CATO-C4X-123939)
- Obeticholic Acid Impurity 39 (CAS 462122-38-9)
- 5-Bromothiophene-2,3-dicarbaldehyde (CAS 37815-80-8)
- Tert-butyl (2-hydroxy-1-(tetrahydro-2h-pyran-3-yl)ethyl)carbamate (CAS 1398503-95-1)
- (1S,8R,Z)-8-aminocyclooct-4-ene-1-carboxylic acid hydrochloride (CAS 350015-75-7)
- 2-Benzyl-2,6-diazaspiro[3.5]Nonane hydrochloride (CAS 1990151-16-0)
- 4-Fluoro-6-methoxypyridin-3-amine (CAS 1805931-15-0)
- 3-Bromo-5,7-dichloro-pyrazolo[1,5-α]pyrimidine (CAS 114040-06-1)
- Des-Lys16-Tirzepatide (CAS CATO-CPTD788957)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com