Paracetamol EP Impurity K HCl CAS 51-78-5
| CAS No. | 51-78-5 |
| Molecular Formula | C6H7NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Paracetamol EP Impurity K HCl (CAS 51-78-5, C6H7NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Paracetamol EP Impurity K HCl is typically white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 145.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H7NO HCl |
| Molecular Weight | 145.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Paracetamol Standards
- Paracetamol (CAS 103-90-2)
- Paracetamol EP Impurity I (CAS 118-93-4)
- Paracetamol EP Impurity K (CAS 123-30-8)
- Paracetamol EP Impurity B (CAS 1693-37-4)
- Paracetamol EP Impurity M (CAS 1752-24-5)
- Paracetamol EP Impurity M HCl (CAS 1965310-24-0)
- Paracetamol EP Impurity L (CAS 2514961-29-4)
- Paracetamol EP Impurity O (CAS 2575516-61-7)
Recommended Standards
- Etonogestrel Impurity 2 (CAS 946163-50-4)
- Rimegepant Impurity 50 (CAS CATO-C4X-248750)
- Ceftazidime Impurity 90 (CAS CATO-C4X-121290)
- Azetidine-1-carbonyl Chloride (CAS 75485-12-0)
- 3-(3-(Trifluoromethoxy)phenyl)propanoic acid (CAS 168833-77-0)
- 1-(Cyclohexylmethyl)-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1430750-97-2)
- Tirofiban Impurity 84 (CAS CATO-C4X-125484)
- (S)-3-Amino-4-(4-methoxyphenyl)butanoic acid hydrochloride (CAS 1421258-68-5)
- 2-Oxa-5-azabicyclo[2.2.2]octane (CAS 280-51-3)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
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