Paracetamol EP Impurity M CAS 1752-24-5
| CAS No. | 1752-24-5 |
| Molecular Formula | C12H11NO2 |
| Molecular Weight | 201.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Paracetamol EP Impurity M (CAS 1752-24-5, C12H11NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Paracetamol EP Impurity M (C12H11NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11NO2 |
| Molecular Weight | 201.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Paracetamol Standards
- Paracetamol EP Impurity C (CAS 3964-54-3)
- Paracetamol EP Impurity J (CAS 539-03-7)
- Paracetamol EP Impurity B (CAS 1693-37-4)
- Paracetamol EP Impurity A (CAS 614-80-2)
- Paracetamol EP Impurity G (CAS 34523-34-7)
- Paracetamol (CAS 103-90-2)
- Paracetamol Cysteine (CAS 58109-87-8)
- Paracetamol EP Impurity I (CAS 118-93-4)
Recommended Standards
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- Flurbiprofen Impurity 21 (Mixture of Diastereomers) (CAS 124635-84-3)
- Paliperidone Impurity 102 (CAS 913728-83-3)
- methyl 5-hydroxy-3-methoxynaphthalene-2-carboxylate (CAS 1341035-71-9)
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- 11-Hydroxy Mexrenone (CAS 192704-56-6)
- Tert-butyl 2-(2-(2-chlorophenoxy)-1-iminoethyl)hydrazine-1-carboxylate (CAS 1053655-91-6)
- [2-(methylsulfanyl)pyrimidin-5-yl]boronic acid (CAS 348098-29-3)
- Dapagliflozin Impurity 144 (CAS 1408245-02-2)
- Semaglutide impurity 193 (CAS CATO-C4X-2226193)
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