Paracetamol EP Impurity I CAS 118-93-4
| CAS No. | 118-93-4 |
| Molecular Formula | C8H8O2 |
| Molecular Weight | 136.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Paracetamol EP Impurity I is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Paracetamol EP Impurity I (CAS 118-93-4, C8H8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Paracetamol EP Impurity I (C8H8O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 136.15 g/mol, it falls into the low-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Paracetamol EP Impurity I under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8O2 |
| Molecular Weight | 136.15 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Paracetamol Standards
- Paracetamol EP Impurity E (CAS 99-93-4)
- Paracetamol EP Impurity A (CAS 614-80-2)
- Paracetamol EP Impurity G (CAS 34523-34-7)
- Paracetamol (CAS 103-90-2)
- Paracetamol EP Impurity K (CAS 123-30-8)
- Paracetamol EP Impurity B (CAS 1693-37-4)
- Paracetamol EP Impurity J (CAS 539-03-7)
- Paracetamol EP Impurity C (CAS 3964-54-3)
Recommended Standards
- Sorafenib Impurity 24 (CAS 6144-78-1)
- Imatinib Impurity 63 (CAS 99-94-5)
- Guaiacol EP Impurity E (CAS 93-58-3)
- Topiroxostat impurity 74 (CAS CATO-C4X-105574)
- Lornoxicam Impurity 29 (CAS CATO-C4X-201629)
- Clindamycin Impurity 36(Mixture of Z and E Isomers) (CAS CATO-C4X-134136)
- Lornoxicam Impurity 37 (CAS 106820-63-7)
- Verminoside (CAS 50932-19-9)
- N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide (CAS 247923-41-7)
- 2-(2-(4-Fluoro-2-methylphenoxy)ethyl)-1,3-dioxane (CAS 1443305-17-6)
- 1-bromo-dibenzofuran-4-ol (CAS 873974-43-7)
- 3-(4-Chlorophenyl)-1-[(2,4-dichlorophenyl)amino]-2,5-dihydro-1H-pyrrole-2,5-dione (CAS 271254-71-8)
- Avanafil Impurity 70 (CAS 32897-26-0)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com