Tenofovir disoproxil Impurity 3 CAS 52364-31-5
| CAS No. | 52364-31-5 |
| Molecular Formula | C13H13O4P |
| Molecular Weight | 264.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Tenofovir disoproxil Impurity 3 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 264.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Tenofovir disoproxil Impurity 3 (CAS 52364-31-5, C13H13O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tenofovir disoproxil Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H13O4P |
| Molecular Weight | 264.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
Related Tenofovir Standards
- Tenofovir Impurity 38 (CAS 161760-09-4)
- Tenofovir Alafenamide Impurity 29 (CAS CATO-C4X-179729)
- Tenofovir Alafenamide Impurity 26 (CAS CATO-C4X-179726)
- Tenofovir Alafenamide Impurity 47 (CAS 1884329-63-8)
- Tenofovir disoproxil Impurity 42 (CAS 1878175-82-6)
- rac-Tenofovir (CAS 2667563-23-5)
- Tenofovir disoproxil Impurity 105 (CAS 2361988-22-7)
- Tenofovir disoproxil Impurity 120 (CAS 1878175-75-7)
Recommended Standards
- Diethyl (3,4-difluorobenzyl)phosphonate (CAS 451455-95-1)
- Methyl diphenyl phosphate (CAS 115-89-9)
- Diethyl (2,5-difluorobenzyl)phosphonate (CAS 451455-94-0)
- Sitagliptin Impurity 51 (CAS 1485732-85-1)
- Milbemycin Oxime EP Impurity I (CAS CATO-C4X-169811)
- Edoxaban N-Oxide Monomer Impurity 1 (CAS 1974272-82-6)
- Fluvoxamine EP Impurity J (CAS 1217241-15-0)
- 3-(Triisopropylsilyl)propiolic acid (CAS 839697-82-4)
- 2-(3-Oxopropoxy)acetic acid (CAS 87706-87-4)
- Ethyl 2-iodobenzoate (CAS 1829-28-3)
- N-[(1-Boc-4-piperidyl)methyl]pyrimidin-2-amine (CAS 1420889-45-7)
- 4-(4-Hydroxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride (CAS 1808717-05-6)
- 6-Amino-1-benzyl-5-[(2-hydroxyethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 380433-19-2)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com